BRD-A24021119_NCGC00183696-01_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-A24021119_NCGC00183696-01_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
BBX bobby sox homolog (Drosophila)
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CA9 carbonic anhydrase IX
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNG1 cyclin G1
CD69 CD69 molecule
CFDP1 craniofacial development protein 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERO1L ERO1-like (S. cerevisiae)
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FAM162A family with sequence similarity 162, member A
FAM57A family with sequence similarity 57, member A
FN1 fibronectin 1
GATA6 GATA binding protein 6
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLRX glutaredoxin (thioltransferase)
GPI glucose-6-phosphate isomerase
GPX3 glutathione peroxidase 3
GRB10 growth factor receptor-bound protein 10
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG2 insulin induced gene 2
JCHAIN joining chain of multimeric IgA and IgM
JUP junction plakoglobin
KDM3A lysine (K)-specific demethylase 3A
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LOX lysyl oxidase
MLF1 myeloid leukemia factor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
NARF nuclear prelamin A recognition factor
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NMRK1 nicotinamide riboside kinase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPTX2 neuronal pentraxin II
NRN1 neuritin 1
OPN3 opsin 3
OPTN optineurin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFA platelet-derived growth factor alpha polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHYH phytanoyl-CoA 2-hydroxylase
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RRAGD Ras-related GTP binding D
SDC2 syndecan 2
SKAP2 src kinase associated phosphoprotein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG4 sperm associated antigen 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TNIP1 TNFAIP3 interacting protein 1
TRIM22 tripartite motif containing 22
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
YEATS2 YEATS domain containing 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CCNF cyclin F
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CDC25B cell division cycle 25B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DKK1 dickkopf WNT signaling pathway inhibitor 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB3 high mobility group box 3
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IRS1 insulin receptor substrate 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LARP4 La ribonucleoprotein domain family, member 4
MET MET proto-oncogene, receptor tyrosine kinase
MPPED2 metallophosphoesterase domain containing 2
NAV2 neuron navigator 2
PDE4B phosphodiesterase 4B, cAMP-specific
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK1 polo-like kinase 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRC1 protein regulator of cytokinesis 1
RAB21 RAB21, member RAS oncogene family
RGS10 regulator of G-protein signaling 10
SFRP4 secreted frizzled-related protein 4
SYBU syntabulin (syntaxin-interacting)
TDO2 tryptophan 2,3-dioxygenase
TPD52L1 tumor protein D52-like 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)