BRD-A24021119_NCGC00183696-01_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

326 genes differentially expressed following the BRD-A24021119_NCGC00183696-01_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
AREG amphiregulin
ATF3 activating transcription factor 3
BCL2L1 BCL2-like 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
COL14A1 collagen, type XIV, alpha 1
COL8A2 collagen, type VIII, alpha 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTGF connective tissue growth factor
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM13A family with sequence similarity 13, member A
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBE1 glucan (1,4-alpha-), branching enzyme 1
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
GSPT2 G1 to S phase transition 2
HBEGF heparin-binding EGF-like growth factor
HEPH hephaestin
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IL11 interleukin 11
IL33 interleukin 33
INHBA inhibin, beta A
INHBB inhibin, beta B
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLK6 kallikrein-related peptidase 6
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LAMC2 laminin, gamma 2
LARP6 La ribonucleoprotein domain family, member 6
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIF leukemia inhibitory factor
LXN latexin
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MOSPD1 motile sperm domain containing 1
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PDLIM5 PDZ and LIM domain 5
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSD3 pleckstrin and Sec7 domain containing 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RRAD Ras-related associated with diabetes
RSL1D1 ribosomal L1 domain containing 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMD4A sterile alpha motif domain containing 4A
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TGFB2 transforming growth factor, beta 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VLDLR very low density lipoprotein receptor
ZFP36L2 ZFP36 ring finger protein-like 2
ZMAT3 zinc finger, matrin-type 3
ZNF12 zinc finger protein 12
ZNF195 zinc finger protein 195
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ADCY9 adenylate cyclase 9
ADD1 adducin 1 (alpha)
ADGRA3 adhesion G protein-coupled receptor A3
ADGRG6 adhesion G protein-coupled receptor G6
AIM2 absent in melanoma 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CDCA3 cell division cycle associated 3
CDH19 cadherin 19, type 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKAP2 cytoskeleton associated protein 2
COL3A1 collagen, type III, alpha 1
CPD carboxypeptidase D
CPT1A carnitine palmitoyltransferase 1A (liver)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ELAVL1 ELAV like RNA binding protein 1
ELOVL2 ELOVL fatty acid elongase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM64A family with sequence similarity 64, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FKBP5 FK506 binding protein 5
FOXM1 forkhead box M1
FZD2 frizzled class receptor 2
GPSM2 G-protein signaling modulator 2
GRB14 growth factor receptor-bound protein 14
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPM heterogeneous nuclear ribonucleoprotein M
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGSF3 immunoglobulin superfamily, member 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INPP5F inositol polyphosphate-5-phosphatase F
JADE2 jade family PHD finger 2
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KRT18 keratin 18, type I
LBR lamin B receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LMNB1 lamin B1
LMNB2 lamin B2
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
METTL7A methyltransferase like 7A
MKI67 marker of proliferation Ki-67
MSH6 mutS homolog 6
MX2 MX dynamin-like GTPase 2
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NEFH neurofilament, heavy polypeptide
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NMT1 N-myristoyltransferase 1
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PBK PDZ binding kinase
PDS5A PDS5 cohesin associated factor A
PDZK1 PDZ domain containing 1
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RAB8A RAB8A, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
SELL selectin L
SEPHS1 selenophosphate synthetase 1
SFTPB surfactant protein B
SHCBP1 SHC SH2-domain binding protein 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SNX10 sorting nexin 10
SORBS3 sorbin and SH3 domain containing 3
SOX2 SRY (sex determining region Y)-box 2
SPAG5 sperm associated antigen 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBL1X transducin (beta)-like 1X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TROAP trophinin associated protein
TSPAN13 tetraspanin 13
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican