BRD-A23801136_Rifabutin_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-A23801136_Rifabutin_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACAT2 acetyl-CoA acetyltransferase 2
ADCY2 adenylate cyclase 2 (brain)
ALB albumin
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA4 annexin A4
AREG amphiregulin
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASPN asporin
BGN biglycan
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALR calreticulin
CAST calpastatin
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CEP57 centrosomal protein 57kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
COL11A1 collagen, type XI, alpha 1
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRIP2 cysteine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
DAAM2 dishevelled associated activator of morphogenesis 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOCK4 dedicator of cytokinesis 4
DSP desmoplakin
EIF4A1 eukaryotic translation initiation factor 4A1
EPAS1 endothelial PAS domain protein 1
ETNPPL ethanolamine-phosphate phospho-lyase
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FN1 fibronectin 1
FST follistatin
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GFAP glial fibrillary acidic protein
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
IPO13 importin 13
IRF6 interferon regulatory factor 6
KLHDC3 kelch domain containing 3
KLK5 kallikrein-related peptidase 5
KRT23 keratin 23, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAP7 microtubule-associated protein 7
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MPO myeloperoxidase
MT1E metallothionein 1E
MUC16 mucin 16, cell surface associated
NARFL nuclear prelamin A recognition factor-like
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NIT1 nitrilase 1
PAPD7 PAP associated domain containing 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PEG10 paternally expressed 10
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAU plasminogen activator, urokinase
PMM2 phosphomannomutase 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB27A RAB27A, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCRG1 stimulator of chondrogenesis 1
SHB Src homology 2 domain containing adaptor protein B
SNX7 sorting nexin 7
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
SYNM synemin, intermediate filament protein
TDO2 tryptophan 2,3-dioxygenase
TF transferrin
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZIC1 Zic family member 1
ZNF395 zinc finger protein 395
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA3 annexin A3
ANXA5 annexin A5
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
AURKA aurora kinase A
CALU calumenin
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLIC1 chloride intracellular channel 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
DYNLT3 dynein, light chain, Tctex-type 3
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
ETF1 eukaryotic translation termination factor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IL6ST interleukin 6 signal transducer
ITGB1BP1 integrin beta 1 binding protein 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0100 KIAA0100
KRT10 keratin 10, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
NAAA N-acylethanolamine acid amidase
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCYOX1L prenylcysteine oxidase 1 like
PGK1 phosphoglycerate kinase 1
PLAC8 placenta-specific 8
PLK2 polo-like kinase 2
PNMA1 paraneoplastic Ma antigen 1
PPARG peroxisome proliferator-activated receptor gamma
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRDX4 peroxiredoxin 4
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RASA4 RAS p21 protein activator 4
RBP1 retinol binding protein 1, cellular
RPL27A ribosomal protein L27a
RPL36AL ribosomal protein L36a-like
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SACS sacsin molecular chaperone
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SRSF9 serine/arginine-rich splicing factor 9
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TSPAN8 tetraspanin 8
UGCG UDP-glucose ceramide glucosyltransferase
WBSCR22 Williams Beuren syndrome chromosome region 22
ZBTB38 zinc finger and BTB domain containing 38