BRD-A23770159_Rapamycin_MDST8_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-A23770159_Rapamycin_MDST8_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD36B ankyrin repeat domain 36B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
COL4A1 collagen, type IV, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
CTSA cathepsin A
CTSV cathepsin V
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEPTOR DEP domain containing MTOR-interacting protein
DICER1 dicer 1, ribonuclease type III
EDNRA endothelin receptor type A
EFNA1 ephrin-A1
ELF1 E74-like factor 1 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBLN5 fibulin 5
FNDC3B fibronectin type III domain containing 3B
FOXN3 forkhead box N3
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPA2 heat shock 70kDa protein 2
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1A interleukin 1, alpha
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
LAMB1 laminin, beta 1
LGALS8 lectin, galactoside-binding, soluble, 8
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
MFAP2 microfibrillar-associated protein 2
MMP11 matrix metallopeptidase 11
NID2 nidogen 2 (osteonidogen)
NREP neuronal regeneration related protein
OSR2 odd-skipped related transciption factor 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAGL1 pleiomorphic adenoma gene-like 1
PLSCR3 phospholipid scramblase 3
PNRC1 proline-rich nuclear receptor coactivator 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
RAB40B RAB40B, member RAS oncogene family
RNASE4 ribonuclease, RNase A family, 4
SCGB1D2 secretoglobin, family 1D, member 2
SFRP1 secreted frizzled-related protein 1
SNX7 sorting nexin 7
SOD2 superoxide dismutase 2, mitochondrial
SRPX sushi-repeat containing protein, X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TXNIP thioredoxin interacting protein
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADORA2B adenosine A2b receptor
ATM ATM serine/threonine kinase
BEX1 brain expressed, X-linked 1
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EDRF1 erythroid differentiation regulatory factor 1
EMP1 epithelial membrane protein 1
F12 coagulation factor XII (Hageman factor)
FADS1 fatty acid desaturase 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KPNA6 karyopherin alpha 6 (importin alpha 7)
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MYBPC1 myosin binding protein C, slow type
NABP2 nucleic acid binding protein 2
NDRG3 NDRG family member 3
PDLIM5 PDZ and LIM domain 5
PNP purine nucleoside phosphorylase
POU2AF1 POU class 2 associating factor 1
PPID peptidylprolyl isomerase D
PRR7 proline rich 7 (synaptic)
RRM2 ribonucleotide reductase M2
RSL1D1 ribosomal L1 domain containing 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SFN stratifin
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC35F2 solute carrier family 35, member F2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TGOLN2 trans-golgi network protein 2
TLR4 toll-like receptor 4
TPD52L2 tumor protein D52-like 2
TRIM16 tripartite motif containing 16
TUBD1 tubulin, delta 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF430 zinc finger protein 430
ZNF652 zinc finger protein 652