BRD-A23689620_Avermectin B1a_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-A23689620_Avermectin B1a_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAST calpastatin
CBS cystathionine-beta-synthase
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCA4 chloride channel accessory 4
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DOK5 docking protein 5
DUOX2 dual oxidase 2
DUSP4 dual specificity phosphatase 4
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
KLK10 kallikrein-related peptidase 10
KRT23 keratin 23, type I
KRT81 keratin 81, type II
KYNU kynureninase
LCN2 lipocalin 2
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAST4 microtubule associated serine/threonine kinase family member 4
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MUC2 mucin 2, oligomeric mucus/gel-forming
NCAM1 neural cell adhesion molecule 1
NFIL3 nuclear factor, interleukin 3 regulated
NMU neuromedin U
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNOC prepronociceptin
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SARS seryl-tRNA synthetase
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SNAI2 snail family zinc finger 2
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TFPI2 tissue factor pathway inhibitor 2
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD52 CD52 molecule
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
GAS2L1 growth arrest-specific 2 like 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTP1 glutathione S-transferase pi 1
H2AFX H2A histone family, member X
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LAGE3 L antigen family, member 3
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MSX1 msh homeobox 1
NEK7 NIMA-related kinase 7
NQO1 NAD(P)H dehydrogenase, quinone 1
PCNA proliferating cell nuclear antigen
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
RBBP7 retinoblastoma binding protein 7
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMEM14A transmembrane protein 14A
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
ZWINT ZW10 interacting kinetochore protein