BRD-A23637604_oxymetholone_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

402 genes differentially expressed following the BRD-A23637604_oxymetholone_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD3 abhydrolase domain containing 3
ACLY ATP citrate lyase
ACOT9 acyl-CoA thioesterase 9
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
ANPEP alanyl (membrane) aminopeptidase
ANXA5 annexin A5
APOD apolipoprotein D
AREG amphiregulin
ARF4 ADP-ribosylation factor 4
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARMCX3 armadillo repeat containing, X-linked 3
ATF5 activating transcription factor 5
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAS1 breast carcinoma amplified sequence 1
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CIB1 calcium and integrin binding 1 (calmyrin)
COPB1 coatomer protein complex, subunit beta 1
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CORO1B coronin, actin binding protein, 1B
CREB3L1 cAMP responsive element binding protein 3-like 1
CTGF connective tissue growth factor
CUX2 cut-like homeobox 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DERL2 derlin 2
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DYNLRB1 dynein, light chain, roadblock-type 1
EAF2 ELL associated factor 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERGIC2 ERGIC and golgi 2
ETNK1 ethanolamine kinase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM114A1 family with sequence similarity 114, member A1
FAM134B family with sequence similarity 134, member B
FAM189A2 family with sequence similarity 189, member A2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXJ3 forkhead box J3
FOXO4 forkhead box O4
GABARAPL2 GABA(A) receptor-associated protein-like 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
GOLGB1 golgin B1
GOLT1B golgi transport 1B
HES1 hes family bHLH transcription factor 1
HGD homogentisate 1,2-dioxygenase
HOMER2 homer scaffolding protein 2
HPCAL1 hippocalcin-like 1
HSPA2 heat shock 70kDa protein 2
ICAM3 intercellular adhesion molecule 3
IDI1 isopentenyl-diphosphate delta isomerase 1
INPP1 inositol polyphosphate-1-phosphatase
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1324 KIAA1324
KLK2 kallikrein-related peptidase 2
LDLR low density lipoprotein receptor
LGMN legumain
LHFPL2 lipoma HMGIC fusion partner-like 2
LRRC16A leucine rich repeat containing 16A
LTF lactotransferrin
MAGED1 melanoma antigen family D1
MAPK6 mitogen-activated protein kinase 6
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
NANS N-acetylneuraminic acid synthase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NRN1 neuritin 1
OAT ornithine aminotransferase
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDLIM5 PDZ and LIM domain 5
PGM3 phosphoglucomutase 3
PHF1 PHD finger protein 1
PMEPA1 prostate transmembrane protein, androgen induced 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRSS8 protease, serine, 8
RAB4A RAB4A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RCAN1 regulator of calcineurin 1
RHOC ras homolog family member C
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF103 ring finger protein 103
SAR1B secretion associated, Ras related GTPase 1B
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCAND1 SCAN domain containing 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24C SEC24 family member C
SEC62 SEC62 homolog (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERINC5 serine incorporator 5
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35F2 solute carrier family 35, member F2
SLC44A4 solute carrier family 44, member 4
SNAP23 synaptosomal-associated protein, 23kDa
SOAT1 sterol O-acyltransferase 1
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRP54 signal recognition particle 54kDa
TF transferrin
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM9SF2 transmembrane 9 superfamily member 2
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM41B transmembrane protein 41B
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBB2A tubulin, beta 2A class IIa
WBP1L WW domain binding protein 1-like
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YIPF1 Yip1 domain family, member 1
YIPF6 Yip1 domain family, member 6
ZBTB18 zinc finger and BTB domain containing 18
ZFAND6 zinc finger, AN1-type domain 6

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRE5 adhesion G protein-coupled receptor E5
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
ATAD2 ATPase family, AAA domain containing 2
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AUNIP aurora kinase A and ninein interacting protein
BCHE butyrylcholinesterase
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BTN3A2 butyrophilin, subfamily 3, member A2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
C20ORF27 chromosome 20 open reading frame 27
CCDC85B coiled-coil domain containing 85B
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CLU clusterin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CTSC cathepsin C
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
DSCC1 DNA replication and sister chromatid cohesion 1
DSG2 desmoglein 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMX2 empty spiracles homeobox 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FAM13A family with sequence similarity 13, member A
FAM216A family with sequence similarity 216, member A
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
FERMT1 fermitin family member 1
FOXM1 forkhead box M1
FXYD5 FXYD domain containing ion transport regulator 5
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HADH hydroxyacyl-CoA dehydrogenase
HDDC2 HD domain containing 2
HEATR1 HEAT repeat containing 1
HJURP Holliday junction recognition protein
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IL1RN interleukin 1 receptor antagonist
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
LAMA4 laminin, alpha 4
LAMP5 lysosomal-associated membrane protein family, member 5
LDB2 LIM domain binding 2
LDHB lactate dehydrogenase B
LGALS4 lectin, galactoside-binding, soluble, 4
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LTA4H leukotriene A4 hydrolase
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAOA monoamine oxidase A
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MID1IP1 MID1 interacting protein 1
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MRPS2 mitochondrial ribosomal protein S2
MRPS27 mitochondrial ribosomal protein S27
MSLN mesothelin
MTA1 metastasis associated 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NMU neuromedin U
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OPN3 opsin 3
ORC6 origin recognition complex, subunit 6
OXCT1 3-oxoacid CoA transferase 1
P3H2 prolyl 3-hydroxylase 2
PA2G4 proliferation-associated 2G4, 38kDa
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKM phosphofructokinase, muscle
PHGDH phosphoglycerate dehydrogenase
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PLK4 polo-like kinase 4
PNP purine nucleoside phosphorylase
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLR1E polymerase (RNA) I polypeptide E, 53kDa
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRR7 proline rich 7 (synaptic)
PRSS21 protease, serine, 21 (testisin)
PSAT1 phosphoserine aminotransferase 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTTG1 pituitary tumor-transforming 1
PUS7 pseudouridylate synthase 7 (putative)
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD54L RAD54-like (S. cerevisiae)
RANBP1 RAN binding protein 1
RCC1 regulator of chromosome condensation 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RNASEH2A ribonuclease H2, subunit A
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
RUVBL2 RuvB-like AAA ATPase 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEPT11 septin 11
SERBP1 SERPINE1 mRNA binding protein 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPA small nuclear ribonucleoprotein polypeptide A
SRSF7 serine/arginine-rich splicing factor 7
ST7 suppression of tumorigenicity 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TKT transketolase
TMEM109 transmembrane protein 109
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TRAP1 TNF receptor-associated protein 1
TRIB1 tribbles pseudokinase 1
TRIM28 tripartite motif containing 28
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
TROAP trophinin associated protein
TTK TTK protein kinase
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UNG uracil-DNA glycosylase
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VSNL1 visinin-like 1
WASF1 WAS protein family, member 1
WDR12 WD repeat domain 12
WNT5A wingless-type MMTV integration site family, member 5A
ZEB2 zinc finger E-box binding homeobox 2
ZWINT ZW10 interacting kinetochore protein