BRD-A23290232_westcort_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-A23290232_westcort_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
C2 complement component 2
CALD1 caldesmon 1
CD163 CD163 molecule
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DPP4 dipeptidyl-peptidase 4
DPT dermatopontin
E2F2 E2F transcription factor 2
EMP1 epithelial membrane protein 1
EVL Enah/Vasp-like
F13A1 coagulation factor XIII, A1 polypeptide
FGG fibrinogen gamma chain
FKBP5 FK506 binding protein 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GLUL glutamate-ammonia ligase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK1 hexokinase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC6 homeobox C6
IL7R interleukin 7 receptor
KLF2 Kruppel-like factor 2
KLF9 Kruppel-like factor 9
KRT15 keratin 15, type I
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFAP5 microfibrillar associated protein 5
MXRA5 matrix-remodelling associated 5
NDNF neuron-derived neurotrophic factor
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PER1 period circadian clock 1
POU2AF1 POU class 2 associating factor 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
REXO2 RNA exonuclease 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN2 reticulon 2
SELENBP1 selenium binding protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLIT2 slit homolog 2 (Drosophila)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STMN2 stathmin 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNC tenascin C
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TWIST1 twist family bHLH transcription factor 1
VSIG4 V-set and immunoglobulin domain containing 4
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ACTN2 actinin, alpha 2
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BTG3 BTG family, member 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CKM creatine kinase, muscle
CLU clusterin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
HOPX HOP homeobox
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
KLHL41 kelch-like family member 41
LCN2 lipocalin 2
LIF leukemia inhibitory factor
LRP4 low density lipoprotein receptor-related protein 4
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MPO myeloperoxidase
MYBPC1 myosin binding protein C, slow type
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL2 myosin, light chain 2, regulatory, cardiac, slow
OLFM4 olfactomedin 4
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RBP1 retinol binding protein 1, cellular
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPIA ribose 5-phosphate isomerase A
RPL39L ribosomal protein L39-like
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SSFA2 sperm specific antigen 2
SYNJ2 synaptojanin 2
TFF3 trefoil factor 3 (intestinal)
TRIM2 tripartite motif containing 2
UPK1B uroplakin 1B
VDAC1 voltage-dependent anion channel 1
WNT5A wingless-type MMTV integration site family, member 5A