BRD-A23072235_PHENIRAMINE MALEATE_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-A23072235_PHENIRAMINE MALEATE_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADA adenosine deaminase
AICDA activation-induced cytidine deaminase
AREG amphiregulin
BEX4 brain expressed, X-linked 4
BID BH3 interacting domain death agonist
CD99 CD99 molecule
CTSZ cathepsin Z
CTTN cortactin
CUX2 cut-like homeobox 2
DUSP4 dual specificity phosphatase 4
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FST follistatin
GAB2 GRB2-associated binding protein 2
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GREB1 growth regulation by estrogen in breast cancer 1
H1F0 H1 histone family, member 0
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IGHMBP2 immunoglobulin mu binding protein 2
IL1A interleukin 1, alpha
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1M metallothionein 1M
MYO6 myosin VI
PDZD2 PDZ domain containing 2
PPARD peroxisome proliferator-activated receptor delta
PXDN peroxidasin
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNX1 runt-related transcription factor 1
SCGB1D2 secretoglobin, family 1D, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
STXBP2 syntaxin binding protein 2
TCTN1 tectonic family member 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMPRSS3 transmembrane protease, serine 3
TNS3 tensin 3
UPK1B uroplakin 1B
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT1 acetyl-CoA acetyltransferase 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AURKA aurora kinase A
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CCNF cyclin F
CD24 CD24 molecule
CDCA4 cell division cycle associated 4
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
COCH cochlin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CYCS cytochrome c, somatic
DNASE1L3 deoxyribonuclease I-like 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FRZB frizzled-related protein
GREM1 gremlin 1, DAN family BMP antagonist
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRWD1 glutamate-rich WD repeat containing 1
HEPH hephaestin
HES1 hes family bHLH transcription factor 1
HSPA9 heat shock 70kDa protein 9 (mortalin)
ITGA8 integrin, alpha 8
KIAA0922 KIAA0922
KIF2C kinesin family member 2C
LGALS4 lectin, galactoside-binding, soluble, 4
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NT5DC2 5'-nucleotidase domain containing 2
OLFM4 olfactomedin 4
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RUFY3 RUN and FYVE domain containing 3
S100P S100 calcium binding protein P
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPRY2 sprouty homolog 2 (Drosophila)
ST7 suppression of tumorigenicity 7
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TP53 tumor protein p53
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
WDR61 WD repeat domain 61