BRD-A22783572_Vinblastine sulfate_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-A22783572_Vinblastine sulfate_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARMCX1 armadillo repeat containing, X-linked 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BASP1 brain abundant, membrane attached signal protein 1
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC4 chloride intracellular channel 4
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FZD5 frizzled class receptor 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GLIPR1 GLI pathogenesis-related 1
GPM6B glycoprotein M6B
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KRT14 keratin 14, type I
KRT17 keratin 17, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSLN mesothelin
MT1E metallothionein 1E
NELL2 NEL-like 2 (chicken)
NR4A3 nuclear receptor subfamily 4, group A, member 3
OSBPL10 oxysterol binding protein-like 10
PDGFC platelet derived growth factor C
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLEKHA5 pleckstrin homology domain containing, family A member 5
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTPRK protein tyrosine phosphatase, receptor type, K
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGS1 regulator of G-protein signaling 1
SCG5 secretogranin V
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SERINC5 serine incorporator 5
SLAMF7 SLAM family member 7
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOCS2 suppressor of cytokine signaling 2
SRGN serglycin
THBS1 thrombospondin 1
TUBA1A tubulin, alpha 1a
TUBB6 tubulin, beta 6 class V
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACO1 aconitase 1, soluble
ADD3 adducin 3 (gamma)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
B3GNT1
BLMH bleomycin hydrolase
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPD carboxypeptidase D
DCN decorin
DPT dermatopontin
ETV1 ets variant 1
F5 coagulation factor V (proaccelerin, labile factor)
GNPDA1 glucosamine-6-phosphate deaminase 1
GPX2 glutathione peroxidase 2
GSTA4 glutathione S-transferase alpha 4
HADH hydroxyacyl-CoA dehydrogenase
HMGA2 high mobility group AT-hook 2
HOXC10 homeobox C10
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MXRA5 matrix-remodelling associated 5
NFIB nuclear factor I/B
NRN1 neuritin 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRDX3 peroxiredoxin 3
PSPH phosphoserine phosphatase
RFC2 replication factor C (activator 1) 2, 40kDa
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD1 SMAD family member 1
SULF1 sulfatase 1
SVIL supervillin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TM4SF1 transmembrane 4 L six family member 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
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