BRD-A22783572_Vinblastine sulfate_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-A22783572_Vinblastine sulfate_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C6ORF62 chromosome 6 open reading frame 62
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHRDL1 chordin-like 1
CRISP3 cysteine-rich secretory protein 3
DENND1B DENN/MADD domain containing 1B
DKK1 dickkopf WNT signaling pathway inhibitor 1
EPCAM epithelial cell adhesion molecule
ESYT1 extended synaptotagmin-like protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOSL1 FOS-like antigen 1
FST follistatin
FSTL1 follistatin-like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GSN gelsolin
HIST1H2AC histone cluster 1, H2ac
HIST1H3H histone cluster 1, H3h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGA6 integrin, alpha 6
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
MAGED2 melanoma antigen family D2
MBNL2 muscleblind-like splicing regulator 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MSMO1 methylsterol monooxygenase 1
NEB nebulin
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NRG1 neuregulin 1
NRP1 neuropilin 1
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PRELP proline/arginine-rich end leucine-rich repeat protein
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SARS seryl-tRNA synthetase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAL1 T-cell acute lymphocytic leukemia 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TGFB2 transforming growth factor, beta 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TNF tumor necrosis factor
TNNC1 troponin C type 1 (slow)
TNNI2 troponin I type 2 (skeletal, fast)
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TUBB6 tubulin, beta 6 class V
TXNIP thioredoxin interacting protein
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADM adrenomedullin
BAALC brain and acute leukemia, cytoplasmic
BZW2 basic leucine zipper and W2 domains 2
C8ORF4 chromosome 8 open reading frame 4
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CHL1 cell adhesion molecule L1-like
CLDN10 claudin 10
COL3A1 collagen, type III, alpha 1
CTBP1 C-terminal binding protein 1
CXCL5 chemokine (C-X-C motif) ligand 5
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
EPN2 epsin 2
ETV1 ets variant 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAR2 fatty acyl CoA reductase 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
H2AFX H2A histone family, member X
HP haptoglobin
HSPA2 heat shock 70kDa protein 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRX5 iroquois homeobox 5
KIAA0101 KIAA0101
LRRC16A leucine rich repeat containing 16A
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MOCOS molybdenum cofactor sulfurase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRCAM neuronal cell adhesion molecule
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDZRN3 PDZ domain containing ring finger 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTPRD protein tyrosine phosphatase, receptor type, D
RGS2 regulator of G-protein signaling 2
SCAF11 SR-related CTD-associated factor 11
SIK1 salt-inducible kinase 1
SMAD1 SMAD family member 1
SOD2 superoxide dismutase 2, mitochondrial
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
TDO2 tryptophan 2,3-dioxygenase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TYRP1 tyrosinase-related protein 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UQCRH ubiquinol-cytochrome c reductase hinge protein
VAV3 vav 3 guanine nucleotide exchange factor
ZNF652 zinc finger protein 652