BRD-A22783572_Vinblastine sulfate_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-A22783572_Vinblastine sulfate_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGAP29 Rho GTPase activating protein 29
ARMCX1 armadillo repeat containing, X-linked 1
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
CA2 carbonic anhydrase II
CAPG capping protein (actin filament), gelsolin-like
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CD200 CD200 molecule
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKB creatine kinase, brain
CLDN3 claudin 3
CLDN4 claudin 4
CTSS cathepsin S
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYBB cytochrome b-245, beta polypeptide
DOCK4 dedicator of cytokinesis 4
DSE dermatan sulfate epimerase
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EPCAM epithelial cell adhesion molecule
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP6 fatty acid binding protein 6, ileal
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
IRF8 interferon regulatory factor 8
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KCNK3 potassium channel, two pore domain subfamily K, member 3
LGALS2 lectin, galactoside-binding, soluble, 2
LTB lymphotoxin beta (TNF superfamily, member 3)
MFAP5 microfibrillar associated protein 5
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NCF1C neutrophil cytosolic factor 1C pseudogene
NCF2 neutrophil cytosolic factor 2
NELL2 NEL-like 2 (chicken)
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PDZK1IP1 PDZK1 interacting protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PTPRK protein tyrosine phosphatase, receptor type, K
REG1A regenerating islet-derived 1 alpha
RTN1 reticulon 1
S100A1 S100 calcium binding protein A1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SORBS2 sorbin and SH3 domain containing 2
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
TCL1A T-cell leukemia/lymphoma 1A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACD adrenocortical dysplasia homolog (mouse)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
B3GNT1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
ELOVL2 ELOVL fatty acid elongase 2
ERGIC3 ERGIC and golgi 3
GAS1 growth arrest-specific 1
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA8 heat shock 70kDa protein 8
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IRS1 insulin receptor substrate 1
KPNB1 karyopherin (importin) beta 1
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MGP matrix Gla protein
MTUS1 microtubule associated tumor suppressor 1
NAE1 NEDD8 activating enzyme E1 subunit 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
WFS1 Wolfram syndrome 1 (wolframin)
ZW10 zw10 kinetochore protein