BRD-A22783572_Vinblastine sulfate_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

300 genes differentially expressed following the BRD-A22783572_Vinblastine sulfate_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
APOA1 apolipoprotein A-I
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BID BH3 interacting domain death agonist
CA2 carbonic anhydrase II
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND1 cyclin D1
CCND2 cyclin D2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD200 CD200 molecule
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD3D CD3d molecule, delta (CD3-TCR complex)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD9 CD9 molecule
CDC34 cell division cycle 34
CDCP1 CUB domain containing protein 1
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIT1 chitinase 1 (chitotriosidase)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKB creatine kinase, brain
CLDN3 claudin 3
CLGN calmegin
CSNK2A2 casein kinase 2, alpha prime polypeptide
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR4 chemokine (C-X-C motif) receptor 4
DENND1B DENN/MADD domain containing 1B
DUSP6 dual specificity phosphatase 6
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM3C family with sequence similarity 3, member C
FN1 fibronectin 1
FST follistatin
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
G0S2 G0/G1 switch 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAL galanin/GMAP prepropeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLRX glutaredoxin (thioltransferase)
HDAC9 histone deacetylase 9
HIRA histone cell cycle regulator
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HSPG2 heparan sulfate proteoglycan 2
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IL1B interleukin 1, beta
IRF6 interferon regulatory factor 6
IRF8 interferon regulatory factor 8
ITGA6 integrin, alpha 6
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAG1 jagged 1
KLK10 kallikrein-related peptidase 10
LAPTM5 lysosomal protein transmembrane 5
LCK LCK proto-oncogene, Src family tyrosine kinase
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
LYZ lysozyme
MARS methionyl-tRNA synthetase
MECOM MDS1 and EVI1 complex locus
MICALL1 MICAL-like 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYO5A myosin VA (heavy chain 12, myoxin)
NELL2 NEL-like 2 (chicken)
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
OSBPL3 oxysterol binding protein-like 3
PEA15 phosphoprotein enriched in astrocytes 15
PERP PERP, TP53 apoptosis effector
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLEK2 pleckstrin 2
PLVAP plasmalemma vesicle associated protein
PMM2 phosphomannomutase 2
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
REEP1 receptor accessory protein 1
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RNF6 ring finger protein (C3H2C3 type) 6
RTCA RNA 3'-terminal phosphate cyclase
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH2B3 SH2B adaptor protein 3
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
TARP TCR gamma alternate reading frame protein
TCL1A T-cell leukemia/lymphoma 1A
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRD T cell receptor delta locus
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TWF1 twinfilin actin binding protein 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP8 vesicle-associated membrane protein 8
WT1 Wilms tumor 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
ASCL1 achaete-scute family bHLH transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BARD1 BRCA1 associated RING domain 1
BASP1 brain abundant, membrane attached signal protein 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BHLHE40 basic helix-loop-helix family, member e40
BMPR1A bone morphogenetic protein receptor, type IA
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C2CD5 C2 calcium-dependent domain containing 5
C8ORF4 chromosome 8 open reading frame 4
CAPN3 calpain 3, (p94)
CBX1 chromobox homolog 1
CCNE2 cyclin E2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFI complement factor I
CLIC3 chloride intracellular channel 3
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COL5A1 collagen, type V, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENSA endosulfine alpha
EPN2 epsin 2
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FHL2 four and a half LIM domains 2
FOXJ3 forkhead box J3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLPH3L golgi phosphoprotein 3-like
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0101 KIAA0101
KRT7 keratin 7, type II
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHX2 LIM homeobox 2
LIG1 ligase I, DNA, ATP-dependent
LMCD1 LIM and cysteine-rich domains 1
LUM lumican
MAB21L1 mab-21-like 1 (C. elegans)
MAGT1 magnesium transporter 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MEIS3P1 Meis homeobox 3 pseudogene 1
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSH6 mutS homolog 6
MSRB2 methionine sulfoxide reductase B2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYH10 myosin, heavy chain 10, non-muscle
MYLK myosin light chain kinase
NAV2 neuron navigator 2
NBN nibrin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
NUP62 nucleoporin 62kDa
OLFML3 olfactomedin-like 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM1 PDZ and LIM domain 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGM1 phosphoglucomutase 1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PRSS23 protease, serine, 23
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRD protein tyrosine phosphatase, receptor type, D
RCAN1 regulator of calcineurin 1
RNASEH2A ribonuclease H2, subunit A
RNMT RNA (guanine-7-) methyltransferase
RRM1 ribonucleotide reductase M1
RUFY3 RUN and FYVE domain containing 3
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIK1 salt-inducible kinase 1
SLC16A4 solute carrier family 16, member 4
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMAD7 SMAD family member 7
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNX11 sorting nexin 11
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SULF1 sulfatase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TMEM14A transmembrane protein 14A
TMEM45A transmembrane protein 45A
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM2 translocation associated membrane protein 2
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUFT1 tuftelin 1
TUSC3 tumor suppressor candidate 3
TXN thioredoxin
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ULK2 unc-51 like autophagy activating kinase 2
UNG uracil-DNA glycosylase
VCAM1 vascular cell adhesion molecule 1
WEE1 WEE1 G2 checkpoint kinase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZCCHC24 zinc finger, CCHC domain containing 24
ZMIZ1 zinc finger, MIZ-type containing 1