BRD-A22783572_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-A22783572_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC2B C-type lectin domain family 2, member B
CREB3L2 cAMP responsive element binding protein 3-like 2
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPAS1 endothelial PAS domain protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATAD1 GATA zinc finger domain containing 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
GRB7 growth factor receptor-bound protein 7
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
ILK integrin-linked kinase
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JAG1 jagged 1
JUN jun proto-oncogene
LHFPL2 lipoma HMGIC fusion partner-like 2
LPP LIM domain containing preferred translocation partner in lipoma
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MBP myelin basic protein
MCTP1 multiple C2 domains, transmembrane 1
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICALL1 MICAL-like 1
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MT1M metallothionein 1M
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NEFL neurofilament, light polypeptide
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFA platelet-derived growth factor alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKCI protein kinase C, iota
PTPRK protein tyrosine phosphatase, receptor type, K
PXDC1 PX domain containing 1
PXN paxillin
RAB32 RAB32, member RAS oncogene family
RGCC regulator of cell cycle
RGS3 regulator of G-protein signaling 3
S100A2 S100 calcium binding protein A2
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STEAP3 STEAP family member 3, metalloreductase
STK26 serine/threonine protein kinase 26
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNJ2 synaptojanin 2
TAGLN2 transgelin 2
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM4 tropomyosin 4
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TXNRD1 thioredoxin reductase 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
ZNF91 zinc finger protein 91
ZYX zyxin

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASCL1 achaete-scute family bHLH transcription factor 1
ASF1B anti-silencing function 1B histone chaperone
ATPIF1 ATPase inhibitory factor 1
B3GNT1
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
C1S complement component 1, s subcomponent
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CHEK2 checkpoint kinase 2
CLIC3 chloride intracellular channel 3
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSV cathepsin V
CXCL12 chemokine (C-X-C motif) ligand 12
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DZIP3 DAZ interacting zinc finger protein 3
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELAVL1 ELAV like RNA binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EPHA3 EPH receptor A3
ETV1 ets variant 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLGA8A golgin A8 family, member A
GSTA4 glutathione S-transferase alpha 4
H1FX H1 histone family, member X
HMGB3 high mobility group box 3
HNRNPL heterogeneous nuclear ribonucleoprotein L
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
ILF3 interleukin enhancer binding factor 3, 90kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP5 lysosomal-associated membrane protein family, member 5
LEF1 lymphoid enhancer-binding factor 1
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTBP3 latent transforming growth factor beta binding protein 3
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCKSL1 MARCKS-like 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
METRN meteorin, glial cell differentiation regulator
MRPS16 mitochondrial ribosomal protein S16
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP1 poly (ADP-ribose) polymerase 1
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PDZRN3 PDZ domain containing ring finger 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB4 phospholipase C, beta 4
PNMAL1 paraneoplastic Ma antigen family-like 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRAME preferentially expressed antigen in melanoma
PRDX2 peroxiredoxin 2
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTCH1 patched 1
PTMA prothymosin, alpha
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RBBP4 retinoblastoma binding protein 4
RBP1 retinol binding protein 1, cellular
RER1 retention in endoplasmic reticulum sorting receptor 1
RPA2 replication protein A2, 32kDa
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDF4 stromal cell derived factor 4
SFRP1 secreted frizzled-related protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMAD6 SMAD family member 6
SMYD3 SET and MYND domain containing 3
SOX11 SRY (sex determining region Y)-box 11
SRSF5 serine/arginine-rich splicing factor 5
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF3 trefoil factor 3 (intestinal)
TIMELESS timeless circadian clock
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UNG uracil-DNA glycosylase
VCAM1 vascular cell adhesion molecule 1
VCAN versican
ZWINT ZW10 interacting kinetochore protein