BRD-A22783572_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-A22783572_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSL1 acyl-CoA synthetase long-chain family member 1
ANXA1 annexin A1
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
C9ORF3 chromosome 9 open reading frame 3
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CTGF connective tissue growth factor
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAXX death-domain associated protein
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
EPHA2 EPH receptor A2
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FLNA filamin A, alpha
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GRB10 growth factor receptor-bound protein 10
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
IFRD1 interferon-related developmental regulator 1
INHBB inhibin, beta B
JAG1 jagged 1
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LGALS4 lectin, galactoside-binding, soluble, 4
MAGEA3 melanoma antigen family A3
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBTPS1 membrane-bound transcription factor peptidase, site 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL3 oxysterol binding protein-like 3
PSAT1 phosphoserine aminotransferase 1
PTPRE protein tyrosine phosphatase, receptor type, E
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RNF19B ring finger protein 19B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN2 reticulon 2
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
STAR steroidogenic acute regulatory protein
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM1 tropomyosin 1 (alpha)
TUBB2A tubulin, beta 2A class IIa
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
ZYX zyxin

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALG8 ALG8, alpha-1,3-glucosyltransferase
ARMT1 acidic residue methyltransferase 1
B3GNT1
C14ORF1 chromosome 14 open reading frame 1
C1S complement component 1, s subcomponent
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
CCND1 cyclin D1
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CFB complement factor B
CHEK2 checkpoint kinase 2
CYB5A cytochrome b5 type A (microsomal)
DCXR dicarbonyl/L-xylulose reductase
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
ESR1 estrogen receptor 1
FAM63A family with sequence similarity 63, member A
FEN1 flap structure-specific endonuclease 1
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPC3 glypican 3
GSTM3 glutathione S-transferase mu 3 (brain)
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H4C histone cluster 1, H4c
HLF hepatic leukemia factor
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGL immunoglobulin lambda locus
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISOC1 isochorismatase domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MCM2 minichromosome maintenance complex component 2
MGP matrix Gla protein
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
PCNA proliferating cell nuclear antigen
PRKCD protein kinase C, delta
QDPR quinoid dihydropteridine reductase
RAB31 RAB31, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASE4 ribonuclease, RNase A family, 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SRSF1 serine/arginine-rich splicing factor 1
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
SUB1 SUB1 homolog (S. cerevisiae)
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMEM109 transmembrane protein 109
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)