BRD-A22783572_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-A22783572_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANO1 anoctamin 1, calcium activated chloride channel
ANXA3 annexin A3
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARF4 ADP-ribosylation factor 4
AXL AXL receptor tyrosine kinase
BASP1 brain abundant, membrane attached signal protein 1
BIRC2 baculoviral IAP repeat containing 2
CAB39 calcium binding protein 39
CAPN2 calpain 2, (m/II) large subunit
CD58 CD58 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY1 cryptochrome circadian clock 1
CTBP2 C-terminal binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GDF15 growth differentiation factor 15
GOLM1 golgi membrane protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX1 glutathione peroxidase 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IFI27 interferon, alpha-inducible protein 27
INHBA inhibin, beta A
IQCG IQ motif containing G
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PALLD palladin, cytoskeletal associated protein
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PPARD peroxisome proliferator-activated receptor delta
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRSS23 protease, serine, 23
PTP4A1 protein tyrosine phosphatase type IVA, member 1
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPTAN1 spectrin, alpha, non-erythrocytic 1
STK17A serine/threonine kinase 17a
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TJP1 tight junction protein 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNPO1 transportin 1
TPM1 tropomyosin 1 (alpha)
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
ARID5B AT rich interactive domain 5B (MRF1-like)
BHLHE41 basic helix-loop-helix family, member e41
CD200 CD200 molecule
CP ceruloplasmin (ferroxidase)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
GAGE3 G antigen 3
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPC3 glypican 3
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIF20A kinesin family member 20A
LAMP3 lysosomal-associated membrane protein 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NRN1 neuritin 1
OBSL1 obscurin-like 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SALL2 spalt-like transcription factor 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX11 SRY (sex determining region Y)-box 11
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB2 tribbles pseudokinase 2