BRD-A22783572_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-A22783572_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARF4 ADP-ribosylation factor 4
ARMCX3 armadillo repeat containing, X-linked 3
BIRC2 baculoviral IAP repeat containing 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CST3 cystatin C
CST6 cystatin E/M
CXCL14 chemokine (C-X-C motif) ligand 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
INHBA inhibin, beta A
KLF6 Kruppel-like factor 6
KLK7 kallikrein-related peptidase 7
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
MAB21L2 mab-21-like 2 (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSMO1 methylsterol monooxygenase 1
NNMT nicotinamide N-methyltransferase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
RND3 Rho family GTPase 3
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQSTM1 sequestosome 1
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TJP2 tight junction protein 2
TMEM45A transmembrane protein 45A
TPM4 tropomyosin 4
TSC22D2 TSC22 domain family, member 2
TUBB6 tubulin, beta 6 class V
UGCG UDP-glucose ceramide glucosyltransferase
VNN1 vanin 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKB creatine kinase, brain
CPA3 carboxypeptidase A3 (mast cell)
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
ERBB2 erb-b2 receptor tyrosine kinase 2
FCGBP Fc fragment of IgG binding protein
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSTM3 glutathione S-transferase mu 3 (brain)
HNMT histamine N-methyltransferase
LEF1 lymphoid enhancer-binding factor 1
MPPED2 metallophosphoesterase domain containing 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLBD1 phospholipase B domain containing 1
PPAP2B phosphatidic acid phosphatase type 2B
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TBX3 T-box 3
WNT5A wingless-type MMTV integration site family, member 5A
ZNF586 zinc finger protein 586