BRD-A22783572_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-A22783572_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ACTN4 actinin, alpha 4
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
CALML3 calmodulin-like 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CDA cytidine deaminase
CRISP3 cysteine-rich secretory protein 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DSG1 desmoglein 1
EGFR epidermal growth factor receptor
EPHB2 EPH receptor B2
FERMT2 fermitin family member 2
FHOD3 formin homology 2 domain containing 3
FLG filaggrin
G0S2 G0/G1 switch 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPM6B glycoprotein M6B
HCAR3 hydroxycarboxylic acid receptor 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
MAP1B microtubule-associated protein 1B
MCUR1 mitochondrial calcium uniporter regulator 1
MGLL monoglyceride lipase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NBL1 neuroblastoma 1, DAN family BMP antagonist
PYGB phosphorylase, glycogen; brain
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFN stratifin
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMTN smoothelin
SQLE squalene epoxidase
SQRDL sulfide quinone reductase-like (yeast)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFBI transforming growth factor, beta-induced, 68kDa
TPM1 tropomyosin 1 (alpha)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
ZBTB16 zinc finger and BTB domain containing 16
ZMYM2 zinc finger, MYM-type 2
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASPN asporin
ASS1 argininosuccinate synthase 1
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
C1ORF61 chromosome 1 open reading frame 61
CD99 CD99 molecule
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFI complement factor I
CXCL10 chemokine (C-X-C motif) ligand 10
CYBA cytochrome b-245, alpha polypeptide
EMP1 epithelial membrane protein 1
FAR2 fatty acyl CoA reductase 2
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GLRX glutaredoxin (thioltransferase)
HEG1 heart development protein with EGF-like domains 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-F major histocompatibility complex, class I, F
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1598
KLHL9 kelch-like family member 9
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
MAOB monoamine oxidase B
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
MX1 MX dynamin-like GTPase 1
MXRA5 matrix-remodelling associated 5
MYRF myelin regulatory factor
NQO1 NAD(P)H dehydrogenase, quinone 1
PDZK1 PDZ domain containing 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLIN2 perilipin 2
PROM1 prominin 1
RAP1GAP RAP1 GTPase activating protein
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A4 solute carrier family 16, member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SULF1 sulfatase 1
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN6 tetraspanin 6
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
WEE1 WEE1 G2 checkpoint kinase