BRD-A22713669_BVT 948_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

318 genes differentially expressed following the BRD-A22713669_BVT 948_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
ACP5 acid phosphatase 5, tartrate resistant
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCK3 aarF domain containing kinase 3
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AMOTL2 angiomotin like 2
AREG amphiregulin
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARMCX1 armadillo repeat containing, X-linked 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAMBI BMP and activin membrane-bound inhibitor
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC85B coiled-coil domain containing 85B
CCNL1 cyclin L1
CCPG1 cell cycle progression 1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN3 claudin 3
COL10A1 collagen, type X, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY1 cryptochrome circadian clock 1
CRYAB crystallin, alpha B
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CTTN cortactin
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOK5 docking protein 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN1 endothelin 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EREG epiregulin
ESRP1 epithelial splicing regulatory protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP7 fatty acid binding protein 7, brain
FAM107A family with sequence similarity 107, member A
FAM134B family with sequence similarity 134, member B
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
IL6 interleukin 6
INHBA inhibin, beta A
ITCH itchy E3 ubiquitin protein ligase
JUN jun proto-oncogene
JUND jun D proto-oncogene
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT34 keratin 34, type I
KRT6B keratin 6B, type II
LARP6 La ribonucleoprotein domain family, member 6
LMCD1 LIM and cysteine-rich domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAL mal, T-cell differentiation protein
MFAP5 microfibrillar associated protein 5
MLF1 myeloid leukemia factor 1
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM5 PDZ and LIM domain 5
PHGDH phosphoglycerate dehydrogenase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G16 phospholipase A2, group XVI
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RNF114 ring finger protein 114
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNX2 sorting nexin 2
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRSF6 serine/arginine-rich splicing factor 6
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAPBPL TAP binding protein-like
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
UBE2H ubiquitin-conjugating enzyme E2H
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZFAND1 zinc finger, AN1-type domain 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANPEP alanyl (membrane) aminopeptidase
APOB apolipoprotein B
ARMC8 armadillo repeat containing 8
ASF1A anti-silencing function 1A histone chaperone
ASPH aspartate beta-hydroxylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C11ORF95 chromosome 11 open reading frame 95
C2CD2 C2 calcium-dependent domain containing 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CKAP4 cytoskeleton-associated protein 4
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A5 collagen, type IV, alpha 5
CPD carboxypeptidase D
CST3 cystatin C
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DICER1 dicer 1, ribonuclease type III
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FAM178A family with sequence similarity 178, member A
FAM3C family with sequence similarity 3, member C
FASTKD5 FAST kinase domains 5
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXA1 forkhead box A1
FZD2 frizzled class receptor 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA10 homeobox A10
HOXA11 homeobox A11
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
KIAA0907 KIAA0907
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT1 keratin 1, type II
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LINC00342 long intergenic non-protein coding RNA 342
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB2 lamin B2
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MCM3 minichromosome maintenance complex component 3
MEIS1 Meis homeobox 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKI67 marker of proliferation Ki-67
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDC80 NDC80 kinetochore complex component
NID1 nidogen 1
NMT1 N-myristoyltransferase 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NT5DC2 5'-nucleotidase domain containing 2
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
PBX1 pre-B-cell leukemia homeobox 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PGK1 phosphoglycerate kinase 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PNISR PNN-interacting serine/arginine-rich protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRC1 protein regulator of cytokinesis 1
PRKCB protein kinase C, beta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSRC1 proline/serine-rich coiled-coil 1
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SGPL1 sphingosine-1-phosphate lyase 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORBS1 sorbin and SH3 domain containing 1
SOX11 SRY (sex determining region Y)-box 11
SPC25 SPC25, NDC80 kinetochore complex component
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SRSF11 serine/arginine-rich splicing factor 11
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TARDBP TAR DNA binding protein
TBC1D2B TBC1 domain family, member 2B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM194A transmembrane protein 194A
TRAK2 trafficking protein, kinesin binding 2
TRIB2 tribbles pseudokinase 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UBE2I ubiquitin-conjugating enzyme E2I
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZFC3H1 zinc finger, C3H1-type containing
ZMYND8 zinc finger, MYND-type containing 8
ZNF512B zinc finger protein 512B