BRD-A22713669_BVT 948_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

301 genes differentially expressed following the BRD-A22713669_BVT 948_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ANGPT2 angiopoietin 2
ARHGAP29 Rho GTPase activating protein 29
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CD93 CD93 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLDN7 claudin 7
CPQ carboxypeptidase Q
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL11 chemokine (C-X-C motif) ligand 11
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DEPTOR DEP domain containing MTOR-interacting protein
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EIF4A1 eukaryotic translation initiation factor 4A1
EMCN endomucin
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
F11R F11 receptor
FBXO11 F-box protein 11
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FRY furry homolog (Drosophila)
FRZB frizzled-related protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GIMAP6 GTPase, IMAP family member 6
GJA1 gap junction protein, alpha 1, 43kDa
GNAS GNAS complex locus
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IL33 interleukin 33
INSM1 insulinoma-associated 1
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
LDB2 LIM domain binding 2
LDB3 LIM domain binding 3
LGMN legumain
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
LRRC32 leucine rich repeat containing 32
LYN LYN proto-oncogene, Src family tyrosine kinase
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBPC1 myosin binding protein C, slow type
MYBPC2 myosin binding protein C, fast type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEB nebulin
NFASC neurofascin
NFIL3 nuclear factor, interleukin 3 regulated
NOX4 NADPH oxidase 4
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
OLFM4 olfactomedin 4
PDLIM5 PDZ and LIM domain 5
PLK2 polo-like kinase 2
PLXNA2 plexin A2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TEK TEK tyrosine kinase, endothelial
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THSD7A thrombospondin, type I, domain containing 7A
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOX thymocyte selection-associated high mobility group box
TPD52 tumor protein D52
TRA2A transformer 2 alpha homolog (Drosophila)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TTN titin
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
AKAP7 A kinase (PRKA) anchor protein 7
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANPEP alanyl (membrane) aminopeptidase
ANXA7 annexin A7
ATF1 activating transcription factor 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CBX3 chromobox homolog 3
CBX6 chromobox homolog 6
CCNA2 cyclin A2
CCNF cyclin F
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDC123 cell division cycle 123
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CETN3 centrin, EF-hand protein, 3
CLCN3 chloride channel, voltage-sensitive 3
CLTB clathrin, light chain B
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COASY CoA synthase
CRLF3 cytokine receptor-like factor 3
CST3 cystatin C
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCXR dicarbonyl/L-xylulose reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECI2 enoyl-CoA delta isomerase 2
EMP3 epithelial membrane protein 3
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETFB electron-transfer-flavoprotein, beta polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM134C family with sequence similarity 134, member C
FKBP10 FK506 binding protein 10, 65 kDa
FXYD5 FXYD domain containing ion transport regulator 5
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLB1 galactosidase, beta 1
GLT8D1 glycosyltransferase 8 domain containing 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLT1B golgi transport 1B
GSTP1 glutathione S-transferase pi 1
GTSE1 G-2 and S-phase expressed 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLTF helicase-like transcription factor
HOXC6 homeobox C6
HSPB11 heat shock protein family B (small), member 11
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFITM2 interferon induced transmembrane protein 2
ITGB1BP1 integrin beta 1 binding protein 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT10 keratin 10, type I
KRT7 keratin 7, type II
LAGE3 L antigen family, member 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPL lipoprotein lipase
LTBP3 latent transforming growth factor beta binding protein 3
LYPLA1 lysophospholipase I
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED1 melanoma antigen family D1
MAN2B1 mannosidase, alpha, class 2B, member 1
MPRIP myosin phosphatase Rho interacting protein
MXRA7 matrix-remodelling associated 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOTCH2 notch 2
NUP62 nucleoporin 62kDa
PBK PDZ binding kinase
PCBP4 poly(rC) binding protein 4
PCOLCE procollagen C-endopeptidase enhancer
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRDX1 peroxiredoxin 1
PRKCA protein kinase C, alpha
PSCA prostate stem cell antigen
PTGDS prostaglandin D2 synthase 21kDa (brain)
QKI QKI, KH domain containing, RNA binding
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REEP5 receptor accessory protein 5
RER1 retention in endoplasmic reticulum sorting receptor 1
RHOA ras homolog family member A
RPA3 replication protein A3, 14kDa
SACS sacsin molecular chaperone
SCP2 sterol carrier protein 2
SCRG1 stimulator of chondrogenesis 1
SEC23A Sec23 homolog A (S. cerevisiae)
SEPT11 septin 11
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SNX10 sorting nexin 10
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D16 TBC1 domain family, member 16
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBI transforming growth factor, beta-induced, 68kDa
TM9SF2 transmembrane 9 superfamily member 2
TMEM2 transmembrane protein 2
TNC tenascin C
TOP2B topoisomerase (DNA) II beta 180kDa
TRAM1 translocation associated membrane protein 1
TRAPPC3 trafficking protein particle complex 3
TRAPPC4 trafficking protein particle complex 4
TRIM14 tripartite motif containing 14
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
TUBG1 tubulin, gamma 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBL4A ubiquitin-like 4A
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNC119B unc-119 homolog B (C. elegans)
USP1 ubiquitin specific peptidase 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDR82 WD repeat domain 82
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YME1L1 YME1-like 1 ATPase
ZCCHC24 zinc finger, CCHC domain containing 24