BRD-A22152765_Tridihexethyl chloride_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-A22152765_Tridihexethyl chloride_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AKR1C3 aldo-keto reductase family 1, member C3
ANXA3 annexin A3
ANXA5 annexin A5
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BCL6 B-cell CLL/lymphoma 6
BST2 bone marrow stromal cell antigen 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP10 dual specificity phosphatase 10
DUSP7 dual specificity phosphatase 7
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GHR growth hormone receptor
GPRC5A G protein-coupled receptor, class C, group 5, member A
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
KIAA0485 uncharacterized LOC57235
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED1 melanoma antigen family D1
MRPS30 mitochondrial ribosomal protein S30
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PRDX2 peroxiredoxin 2
PRKCZ protein kinase C, zeta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QDPR quinoid dihydropteridine reductase
QPCT glutaminyl-peptide cyclotransferase
RAB9A RAB9A, member RAS oncogene family
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RFK riboflavin kinase
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP2 syntaxin binding protein 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TOB1 transducer of ERBB2, 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TSPYL1 TSPY-like 1
UBQLN2 ubiquilin 2

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRF5 adhesion G protein-coupled receptor F5
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C14ORF132 chromosome 14 open reading frame 132
CADM1 cell adhesion molecule 1
CES2 carboxylesterase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC5A C-type lectin domain family 5, member A
COLEC12 collectin sub-family member 12
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
DCHS1 dachsous cadherin-related 1
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FILIP1L filamin A interacting protein 1-like
FRZB frizzled-related protein
GTPBP8 GTP-binding protein 8 (putative)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
ISOC1 isochorismatase domain containing 1
LAMA4 laminin, alpha 4
MAOB monoamine oxidase B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MBD4 methyl-CpG binding domain protein 4
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
NOX4 NADPH oxidase 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM3 PDZ and LIM domain 3
PEG3 paternally expressed 3
PLN phospholamban
PON3 paraoxonase 3
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SFRP4 secreted frizzled-related protein 4
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMAD1 SMAD family member 1
SOX11 SRY (sex determining region Y)-box 11
SULF1 sulfatase 1
TMSB15A thymosin beta 15a
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOR1A torsin family 1, member A (torsin A)
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91