BRD-A22032524_Amlodipine_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-A22032524_Amlodipine_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AUTS2 autism susceptibility candidate 2
BMP2 bone morphogenetic protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ELF5 E74-like factor 5 (ets domain transcription factor)
ENO1 enolase 1, (alpha)
FAM129A family with sequence similarity 129, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFNAR1 interferon (alpha, beta and omega) receptor 1
INSIG1 insulin induced gene 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
NEBL nebulette
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
PNMA2 paraneoplastic Ma antigen 2
RRAGD Ras-related GTP binding D
SDC2 syndecan 2
SNX7 sorting nexin 7
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQLE squalene epoxidase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TMEM45A transmembrane protein 45A
TOPBP1 topoisomerase (DNA) II binding protein 1
TOX3 TOX high mobility group box family member 3
TRIM29 tripartite motif containing 29

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CANT1 calcium activated nucleotidase 1
CCNB2 cyclin B2
CDC20 cell division cycle 20
CLCA1 chloride channel accessory 1
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DLD dihydrolipoamide dehydrogenase
EML3 echinoderm microtubule associated protein like 3
F3 coagulation factor III (thromboplastin, tissue factor)
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
IFI27 interferon, alpha-inducible protein 27
IRS2 insulin receptor substrate 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KANK2 KN motif and ankyrin repeat domains 2
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LHFP lipoma HMGIC fusion partner
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MRPS16 mitochondrial ribosomal protein S16
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAUR plasminogen activator, urokinase receptor
PMEPA1 prostate transmembrane protein, androgen induced 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCAND1 SCAN domain containing 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SPARCL1 SPARC-like 1 (hevin)
TATDN2 TatD DNase domain containing 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2