BRD-A22032524_AMLODIPINE BESYLATE_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-A22032524_AMLODIPINE BESYLATE_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACACA acetyl-CoA carboxylase alpha
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
ANXA5 annexin A5
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
C14ORF1 chromosome 14 open reading frame 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHRDL1 chordin-like 1
CLIC4 chloride intracellular channel 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
G6PD glucose-6-phosphate dehydrogenase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1L hematological and neurological expressed 1-like
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MICA MHC class I polypeptide-related sequence A
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEFL neurofilament, light polypeptide
NPC1 Niemann-Pick disease, type C1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
PHGDH phosphoglycerate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMEPA1 prostate transmembrane protein, androgen induced 1
PRKCH protein kinase C, eta
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F2 solute carrier family 35, member F2
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SQLE squalene epoxidase
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
XBP1 X-box binding protein 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ARG1 arginase 1
BPI bactericidal/permeability-increasing protein
CA2 carbonic anhydrase II
CCNE2 cyclin E2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CGA glycoprotein hormones, alpha polypeptide
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSPA8 heat shock 70kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
LCN2 lipocalin 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
UGDH UDP-glucose 6-dehydrogenase