BRD-A22032524_AMLODIPINE BESYLATE_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

48 genes differentially expressed following the BRD-A22032524_AMLODIPINE BESYLATE_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BST2 bone marrow stromal cell antigen 2
CCK cholecystokinin
CCNG2 cyclin G2
CES1 carboxylesterase 1
CREM cAMP responsive element modulator
CST1 cystatin SN
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GREM1 gremlin 1, DAN family BMP antagonist
GSTP1 glutathione S-transferase pi 1
HLF hepatic leukemia factor
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI30 interferon, gamma-inducible protein 30
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
OPN3 opsin 3
PCP4 Purkinje cell protein 4
SC5D sterol-C5-desaturase
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TXNIP thioredoxin interacting protein
VCAN versican
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CD24 CD24 molecule
COL9A2 collagen, type IX, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
FCGBP Fc fragment of IgG binding protein
FRZB frizzled-related protein
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
SMAD1 SMAD family member 1
TFPI2 tissue factor pathway inhibitor 2