BRD-A22032524_AMLODIPINE BESYLATE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-A22032524_AMLODIPINE BESYLATE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKAP13 A kinase (PRKA) anchor protein 13
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANXA10 annexin A10
ARG1 arginase 1
ARG2 arginase 2
ATF3 activating transcription factor 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
BLNK B-cell linker
CCND2 cyclin D2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CES1 carboxylesterase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC5A C-type lectin domain family 5, member A
CRABP2 cellular retinoic acid binding protein 2
CSTB cystatin B (stefin B)
CTBP2 C-terminal binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAXX death-domain associated protein
DHCR24 24-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIO1 deiodinase, iodothyronine, type I
ELANE elastase, neutrophil expressed
ENO2 enolase 2 (gamma, neuronal)
FABP4 fatty acid binding protein 4, adipocyte
FBXL12 F-box and leucine-rich repeat protein 12
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GNPDA1 glucosamine-6-phosphate deaminase 1
GP2 glycoprotein 2 (zymogen granule membrane)
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HSPA4 heat shock 70kDa protein 4
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
JUP junction plakoglobin
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP11 matrix metallopeptidase 11
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
MX1 MX dynamin-like GTPase 1
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OLFM4 olfactomedin 4
PFKL phosphofructokinase, liver
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPAP2B phosphatidic acid phosphatase type 2B
QPCT glutaminyl-peptide cyclotransferase
RAB21 RAB21, member RAS oncogene family
RGCC regulator of cell cycle
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TBXA2R thromboxane A2 receptor
TESK1 testis-specific kinase 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
BAG2 BCL2-associated athanogene 2
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1R complement component 1, r subcomponent
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHL1 cell adhesion molecule L1-like
COCH cochlin
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM216A family with sequence similarity 216, member A
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GTSE1 G-2 and S-phase expressed 1
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
IFITM2 interferon induced transmembrane protein 2
ITM2A integral membrane protein 2A
KAZN kazrin, periplakin interacting protein
KIAA0125 KIAA0125
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
LAPTM4B lysosomal protein transmembrane 4 beta
LIMA1 LIM domain and actin binding 1
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
OLFM1 olfactomedin 1
OSMR oncostatin M receptor
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PBK PDZ binding kinase
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRC1 protein regulator of cytokinesis 1
PTDSS1 phosphatidylserine synthase 1
RBP1 retinol binding protein 1, cellular
RDX radixin
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35F2 solute carrier family 35, member F2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRP72 signal recognition particle 72kDa
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNE1 spectrin repeat containing, nuclear envelope 1
TACC3 transforming, acidic coiled-coil containing protein 3
TIMP4 TIMP metallopeptidase inhibitor 4
TMF1 TATA element modulatory factor 1
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRBC1 T cell receptor beta constant 1
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S