BRD-A22032524_AMLODIPINE BESYLATE_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-A22032524_AMLODIPINE BESYLATE_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ARMCX1 armadillo repeat containing, X-linked 1
BASP1 brain abundant, membrane attached signal protein 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG2 cyclin G2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFD complement factor D (adipsin)
CHN2 chimerin 2
CST1 cystatin SN
CST3 cystatin C
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHCR7 7-dehydrocholesterol reductase
FADS1 fatty acid desaturase 1
FOXO4 forkhead box O4
GM2A GM2 ganglioside activator
GNPDA1 glucosamine-6-phosphate deaminase 1
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
HBP1 HMG-box transcription factor 1
HK2 hexokinase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHMBP2 immunoglobulin mu binding protein 2
INSIG1 insulin induced gene 1
ITGA10 integrin, alpha 10
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NRGN neurogranin (protein kinase C substrate, RC3)
PBX1 pre-B-cell leukemia homeobox 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
RAB31 RAB31, member RAS oncogene family
RNASE4 ribonuclease, RNase A family, 4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SQLE squalene epoxidase
SRGN serglycin
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TYROBP TYRO protein tyrosine kinase binding protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAM19 ADAM metallopeptidase domain 19
ALCAM activated leukocyte cell adhesion molecule
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD47 CD47 molecule
CDC42 cell division cycle 42
CFLAR CASP8 and FADD-like apoptosis regulator
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
EDN1 endothelin 1
EFNB2 ephrin-B2
EGF epidermal growth factor
EHD1 EH-domain containing 1
ENDOD1 endonuclease domain containing 1
FILIP1L filamin A interacting protein 1-like
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GRWD1 glutamate-rich WD repeat containing 1
HBEGF heparin-binding EGF-like growth factor
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
IL32 interleukin 32
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAP2K3 mitogen-activated protein kinase kinase 3
MINA MYC induced nuclear antigen
MOK MOK protein kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOLC1 nucleolar and coiled-body phosphoprotein 1
OXTR oxytocin receptor
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERTAD2 SERTA domain containing 2
SHB Src homology 2 domain containing adaptor protein B
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD1 SMAD family member 1
SOX9 SRY (sex determining region Y)-box 9
STK17A serine/threonine kinase 17a
TM9SF3 transmembrane 9 superfamily member 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBB2A tubulin, beta 2A class IIa
UGCG UDP-glucose ceramide glucosyltransferase