BRD-A22032524_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

187 genes differentially expressed following the BRD-A22032524_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
ASPN asporin
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
AZU1 azurocidin 1
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
CA12 carbonic anhydrase XII
CASP1 caspase 1, apoptosis-related cysteine peptidase
CFB complement factor B
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN7 claudin 7
CLEC11A C-type lectin domain family 11, member A
COG7 component of oligomeric golgi complex 7
COL15A1 collagen, type XV, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
DCN decorin
DEFB1 defensin, beta 1
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
ELANE elastase, neutrophil expressed
ESR1 estrogen receptor 1
ETFB electron-transfer-flavoprotein, beta polypeptide
FAM129A family with sequence similarity 129, member A
FNDC3B fibronectin type III domain containing 3B
GATAD1 GATA zinc finger domain containing 1
GLRX glutaredoxin (thioltransferase)
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA2 heat shock 70kDa protein 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IL7R interleukin 7 receptor
KLK1 kallikrein 1
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT19 keratin 19, type I
MAPK13 mitogen-activated protein kinase 13
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MFAP5 microfibrillar associated protein 5
MMP7 matrix metallopeptidase 7
NPIPB3 nuclear pore complex interacting protein family, member B3
PERP PERP, TP53 apoptosis effector
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PRTN3 proteinase 3
PXN paxillin
PYCARD PYD and CARD domain containing
RAB25 RAB25, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SATB2 SATB homeobox 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
THBS2 thrombospondin 2
TMEM30B transmembrane protein 30B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAF3IP2 TRAF3 interacting protein 2
VCAN versican
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CACYBP calcyclin binding protein
CAPZB capping protein (actin filament) muscle Z-line, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CD47 CD47 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK4 cyclin-dependent kinase 4
CENPU centromere protein U
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKS2 CDC28 protein kinase regulatory subunit 2
CORO1C coronin, actin binding protein, 1C
CSRP1 cysteine and glycine-rich protein 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DHCR24 24-dehydrocholesterol reductase
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DYNLL1 dynein, light chain, LC8-type 1
DZIP3 DAZ interacting zinc finger protein 3
EIF4E eukaryotic translation initiation factor 4E
ELOVL5 ELOVL fatty acid elongase 5
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERH enhancer of rudimentary homolog (Drosophila)
FABP7 fatty acid binding protein 7, brain
FDFT1 farnesyl-diphosphate farnesyltransferase 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GDI2 GDP dissociation inhibitor 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGN3 high mobility group nucleosomal binding domain 3
HN1L hematological and neurological expressed 1-like
HSPA8 heat shock 70kDa protein 8
HSPB11 heat shock protein family B (small), member 11
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP3 insulin-like growth factor binding protein 3
ITGB5 integrin, beta 5
KIAA0232 KIAA0232
KIF2C kinesin family member 2C
LDHB lactate dehydrogenase B
LIMCH1 LIM and calponin homology domains 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
NAP1L1 nucleosome assembly protein 1-like 1
NEFH neurofilament, heavy polypeptide
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NLGN4X neuroligin 4, X-linked
NREP neuronal regeneration related protein
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP62 nucleoporin 62kDa
PALLD palladin, cytoskeletal associated protein
PANK2 pantothenate kinase 2
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PSIP1 PC4 and SFRS1 interacting protein 1
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBBP4 retinoblastoma binding protein 4
RPA1 replication protein A1, 70kDa
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
SARAF store-operated calcium entry-associated regulatory factor
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEH1L SEH1-like (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SEPP1 selenoprotein P, plasma, 1
SEPT7 septin 7
SERBP1 SERPINE1 mRNA binding protein 1
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SNN stannin
SOX11 SRY (sex determining region Y)-box 11
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SYNM synemin, intermediate filament protein
TDG thymine-DNA glycosylase
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TOX thymocyte selection-associated high mobility group box
TUBB tubulin, beta class I
TUBB2B tubulin, beta 2B class IIb
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WDR1 WD repeat domain 1
XPO1 exportin 1
YBX3 Y box binding protein 3
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta