BRD-A22032524_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-A22032524_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF48 chromosome 6 open reading frame 48
CCL5 chemokine (C-C motif) ligand 5
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK9 dedicator of cytokinesis 9
EMX2 empty spiracles homeobox 2
EPHB2 EPH receptor B2
EVL Enah/Vasp-like
FKBP14 FK506 binding protein 14, 22 kDa
FOSL2 FOS-like antigen 2
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GTF2IRD1 GTF2I repeat domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
KYNU kynureninase
LRRC16A leucine rich repeat containing 16A
MAP7 microtubule-associated protein 7
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MXI1 MAX interactor 1, dimerization protein
MYO10 myosin X
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PER1 period circadian clock 1
PLAT plasminogen activator, tissue
PNMA2 paraneoplastic Ma antigen 2
PPP1R13B protein phosphatase 1, regulatory subunit 13B
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNMT RNA (guanine-7-) methyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATA20 spermatogenesis associated 20
STX1A syntaxin 1A (brain)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TBL2 transducin (beta)-like 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNIP1 TNFAIP3 interacting protein 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB38 zinc finger and BTB domain containing 38
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
ALOX5 arachidonate 5-lipoxygenase
ANGPT1 angiopoietin 1
ANXA1 annexin A1
ANXA10 annexin A10
AQP1 aquaporin 1 (Colton blood group)
ATAD2 ATPase family, AAA domain containing 2
C1ORF116 chromosome 1 open reading frame 116
CALD1 caldesmon 1
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNE1 cyclin E1
CD24 CD24 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN18 claudin 18
CLEC2B C-type lectin domain family 2, member B
COCH cochlin
CRYAB crystallin, alpha B
CXORF57 chromosome X open reading frame 57
CYTL1 cytokine-like 1
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPT dermatopontin
DUSP6 dual specificity phosphatase 6
EPCAM epithelial cell adhesion molecule
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
KRT14 keratin 14, type I
KRT19 keratin 19, type I
LBP lipopolysaccharide binding protein
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR6 lysophosphatidic acid receptor 6
LPL lipoprotein lipase
MTCL1 microtubule crosslinking factor 1
MXRA5 matrix-remodelling associated 5
MYBPC1 myosin binding protein C, slow type
NCAPD3 non-SMC condensin II complex, subunit D3
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
PBX3 pre-B-cell leukemia homeobox 3
PDLIM1 PDZ and LIM domain 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SORBS1 sorbin and SH3 domain containing 1
SPARCL1 SPARC-like 1 (hevin)
STAB1 stabilin 1
TACSTD2 tumor-associated calcium signal transducer 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
THY1 Thy-1 cell surface antigen
TMEM30B transmembrane protein 30B
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa