BRD-A21858158_PRAZIQUANTEL_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-A21858158_PRAZIQUANTEL_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDOB aldolase B, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ASPN asporin
ATF3 activating transcription factor 3
ATXN10 ataxin 10
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BID BH3 interacting domain death agonist
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CALML3 calmodulin-like 3
CD200 CD200 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CES2 carboxylesterase 2
CHGB chromogranin B
CKB creatine kinase, brain
CLCA4 chloride channel accessory 4
CLDN8 claudin 8
COG7 component of oligomeric golgi complex 7
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAXX death-domain associated protein
DENND1B DENN/MADD domain containing 1B
DIO1 deiodinase, iodothyronine, type I
DUOX2 dual oxidase 2
ECI1 enoyl-CoA delta isomerase 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FBLN1 fibulin 1
FBXL12 F-box and leucine-rich repeat protein 12
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FRZB frizzled-related protein
FZD1 frizzled class receptor 1
FZD5 frizzled class receptor 5
GCG glucagon
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA4 heat shock 70kDa protein 4
JCHAIN joining chain of multimeric IgA and IgM
KDR kinase insert domain receptor
LAMP3 lysosomal-associated membrane protein 3
LGALS2 lectin, galactoside-binding, soluble, 2
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MBOAT7 membrane bound O-acyltransferase domain containing 7
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MSMB microseminoprotein, beta-
NELL2 NEL-like 2 (chicken)
NVL nuclear VCP-like
NXN nucleoredoxin
OLFM4 olfactomedin 4
ORC1 origin recognition complex, subunit 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM3 PDZ and LIM domain 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN2 perilipin 2
PLVAP plasmalemma vesicle associated protein
PLXNB2 plexin B2
PPAP2B phosphatidic acid phosphatase type 2B
PRR15L proline rich 15-like
PRSS16 protease, serine, 16 (thymus)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRK protein tyrosine phosphatase, receptor type, K
RAB21 RAB21, member RAS oncogene family
RAI14 retinoic acid induced 14
REEP1 receptor accessory protein 1
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN1 reticulon 1
SCGB1D2 secretoglobin, family 1D, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELENBP1 selenium binding protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC3 structural maintenance of chromosomes 3
SST somatostatin
STC1 stanniocalcin 1
STON1 stonin 1
TBXA2R thromboxane A2 receptor
TCTA T-cell leukemia translocation altered
TESK1 testis-specific kinase 1
TLK2 tousled-like kinase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAP1 TNF receptor-associated protein 1
TRD T cell receptor delta locus
VEGFA vascular endothelial growth factor A
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)
ZG16 zymogen granule protein 16
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACACB acetyl-CoA carboxylase beta
AGR2 anterior gradient 2
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA5 annexin A5
ATMIN ATM interactor
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLDN1 claudin 1
CST3 cystatin C
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FBN1 fibrillin 1
FBN2 fibrillin 2
FOLR1 folate receptor 1 (adult)
GOLGA8A golgin A8 family, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IL1R2 interleukin 1 receptor, type II
ITGAV integrin, alpha V
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA1033 KIAA1033
LAMC2 laminin, gamma 2
LTBP3 latent transforming growth factor beta binding protein 3
LUC7L3 LUC7-like 3 (S. cerevisiae)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYO6 myosin VI
NPC2 Niemann-Pick disease, type C2
OXTR oxytocin receptor
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCDH9 protocadherin 9
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLTP phospholipid transfer protein
RBM25 RNA binding motif protein 25
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPA3 replication protein A3, 14kDa
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS26 ribosomal protein S26
RPS27L ribosomal protein S27-like
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SECISBP2L SECIS binding protein 2-like
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLIT2 slit homolog 2 (Drosophila)
SNX10 sorting nexin 10
SRSF6 serine/arginine-rich splicing factor 6
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
ZCCHC24 zinc finger, CCHC domain containing 24