BRD-A21584801_brivanib_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-A21584801_brivanib_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BANF1 barrier to autointegration factor 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCDC85B coiled-coil domain containing 85B
CCL5 chemokine (C-C motif) ligand 5
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CLU clusterin
COMP cartilage oligomeric matrix protein
COPS7A COP9 signalosome subunit 7A
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DMD dystrophin
DSP desmoplakin
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP6 insulin-like growth factor binding protein 6
IL15 interleukin 15
IL1RN interleukin 1 receptor antagonist
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT8 keratin 8, type II
LGALS2 lectin, galactoside-binding, soluble, 2
LXN latexin
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MOK MOK protein kinase
NXN nucleoredoxin
PERP PERP, TP53 apoptosis effector
PLAC8 placenta-specific 8
PTGES prostaglandin E synthase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOB ras homolog family member B
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
STXBP2 syntaxin binding protein 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VCAN versican
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMD1 adenosylmethionine decarboxylase 1
ATF5 activating transcription factor 5
ATMIN ATM interactor
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
C6ORF62 chromosome 6 open reading frame 62
CD44 CD44 molecule (Indian blood group)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CP ceruloplasmin (ferroxidase)
CRABP1 cellular retinoic acid binding protein 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGG fibrinogen gamma chain
FMO2 flavin containing monooxygenase 2 (non-functional)
FN1 fibronectin 1
GATA3 GATA binding protein 3
HEATR1 HEAT repeat containing 1
HIST1H2BK histone cluster 1, H2bk
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KRT81 keratin 81, type II
LAMP2 lysosomal-associated membrane protein 2
LOC283683 uncharacterized LOC283683
MAOA monoamine oxidase A
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MFAP4 microfibrillar-associated protein 4
NES nestin
NXT2 nuclear transport factor 2-like export factor 2
OAT ornithine aminotransferase
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PRSS2 protease, serine, 2 (trypsin 2)
PRSS8 protease, serine, 8
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS5 regulator of G-protein signaling 5
RPS11 ribosomal protein S11
RSL1D1 ribosomal L1 domain containing 1
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SSBP2 single-stranded DNA binding protein 2
STC1 stanniocalcin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYT1 synaptotagmin I
TFRC transferrin receptor
TMSB15A thymosin beta 15a
TRPS1 trichorhinophalangeal syndrome I