BRD-A21584801_brivanib_MCF7_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-A21584801_brivanib_MCF7_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C6ORF62 chromosome 6 open reading frame 62
CHN1 chimerin 1
CXCL9 chemokine (C-X-C motif) ligand 9
DUSP22 dual specificity phosphatase 22
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FKBP14 FK506 binding protein 14, 22 kDa
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER5 immediate early response 5
IPO13 importin 13
ITM2A integral membrane protein 2A
LYPD1 LY6/PLAUR domain containing 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MN1 meningioma (disrupted in balanced translocation) 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NGRN neugrin, neurite outgrowth associated
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDGFC platelet derived growth factor C
PECR peroxisomal trans-2-enoyl-CoA reductase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMYD3 SET and MYND domain containing 3
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM30B transmembrane protein 30B
TOX thymocyte selection-associated high mobility group box
TPBG trophoblast glycoprotein
TSPAN5 tetraspanin 5
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
CALD1 caldesmon 1
CD38 CD38 molecule
CDK6 cyclin-dependent kinase 6
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CES1 carboxylesterase 1
CHRDL1 chordin-like 1
COL9A3 collagen, type IX, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GSTM3 glutathione S-transferase mu 3 (brain)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
KRT81 keratin 81, type II
L1CAM L1 cell adhesion molecule
LAMB1 laminin, beta 1
LEF1 lymphoid enhancer-binding factor 1
LEFTY2 left-right determination factor 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRRC16A leucine rich repeat containing 16A
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MYLK myosin light chain kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NLRP2 NLR family, pyrin domain containing 2
NPY1R neuropeptide Y receptor Y1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCDH9 protocadherin 9
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLTP phospholipid transfer protein
PON3 paraoxonase 3
POU2AF1 POU class 2 associating factor 1
RAB40B RAB40B, member RAS oncogene family
RAI14 retinoic acid induced 14
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SEPT6 septin 6
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SPAG4 sperm associated antigen 4
SPP1 secreted phosphoprotein 1
TGFBR3 transforming growth factor, beta receptor III
TNC tenascin C
TSPAN8 tetraspanin 8
UBE2A ubiquitin-conjugating enzyme E2A
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VIM vimentin
VLDLR very low density lipoprotein receptor