BRD-A21584801_brivanib_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-A21584801_brivanib_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
CAV1 caveolin 1, caveolae protein, 22kDa
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHGB chromogranin B
CXCL5 chemokine (C-X-C motif) ligand 5
FAM46A family with sequence similarity 46, member A
FBLN5 fibulin 5
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLGA8B golgin A8 family, member B
GULP1 GULP, engulfment adaptor PTB domain containing 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
LAPTM4B lysosomal protein transmembrane 4 beta
LPIN1 lipin 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MX1 MX dynamin-like GTPase 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NXN nucleoredoxin
PCSK1 proprotein convertase subtilisin/kexin type 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
QPCT glutaminyl-peptide cyclotransferase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSAD2 radical S-adenosyl methionine domain containing 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNAP25 synaptosomal-associated protein, 25kDa
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRSF7 serine/arginine-rich splicing factor 7
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
TPD52 tumor protein D52
TRAM1 translocation associated membrane protein 1

decreased expression

Symbol Name
APOC1 apolipoprotein C-I
AREG amphiregulin
C5AR1 complement component 5a receptor 1
CCL4 chemokine (C-C motif) ligand 4
CTSH cathepsin H
CXCR4 chemokine (C-X-C motif) receptor 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FOXF1 forkhead box F1
FPR1 formyl peptide receptor 1
HBB hemoglobin, beta
IGHM immunoglobulin heavy constant mu
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
OXTR oxytocin receptor
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
RPL37A ribosomal protein L37a
SELENBP1 selenium binding protein 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
TLR4 toll-like receptor 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)