BRD-A21584801_brivanib_MCF10A_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-A21584801_brivanib_MCF10A_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD14A abhydrolase domain containing 14A
ACAT2 acetyl-CoA acetyltransferase 2
ADGRG1 adhesion G protein-coupled receptor G1
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
ARHGAP29 Rho GTPase activating protein 29
BASP1 brain abundant, membrane attached signal protein 1
BAX BCL2-associated X protein
BTG2 BTG family, member 2
CAPG capping protein (actin filament), gelsolin-like
CBR3 carbonyl reductase 3
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CELF2 CUGBP, Elav-like family member 2
CLCA2 chloride channel accessory 2
COLEC12 collectin sub-family member 12
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
DDB2 damage-specific DNA binding protein 2, 48kDa
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
FABP4 fatty acid binding protein 4, adipocyte
FAM63A family with sequence similarity 63, member A
FBN1 fibrillin 1
FDXR ferredoxin reductase
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FOXN3 forkhead box N3
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GRAMD3 GRAM domain containing 3
HOPX HOP homeobox
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF2C kinesin family member 2C
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LDOC1 leucine zipper, down-regulated in cancer 1
LXN latexin
MAPK13 mitogen-activated protein kinase 13
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MSMB microseminoprotein, beta-
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYL9 myosin, light chain 9, regulatory
NCF2 neutrophil cytosolic factor 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PRUNE2 prune homolog 2 (Drosophila)
RAP1GAP2 RAP1 GTPase activating protein 2
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS27L ribosomal protein S27-like
S100A4 S100 calcium binding protein A4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
THBS2 thrombospondin 2
TMEM45A transmembrane protein 45A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TRIM22 tripartite motif containing 22
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
AKAP1 A kinase (PRKA) anchor protein 1
C8ORF33 chromosome 8 open reading frame 33
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CXCL3 chemokine (C-X-C motif) ligand 3
DCP2 decapping mRNA 2
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
FBL fibrillarin
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
HOXA5 homeobox A5
HP haptoglobin
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IPO5 importin 5
IQGAP2 IQ motif containing GTPase activating protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LRPPRC leucine-rich pentatricopeptide repeat containing
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM4 minichromosome maintenance complex component 4
MPPED2 metallophosphoesterase domain containing 2
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAT10 N-acetyltransferase 10 (GCN5-related)
NPY1R neuropeptide Y receptor Y1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PPAT phosphoribosyl pyrophosphate amidotransferase
PRAME preferentially expressed antigen in melanoma
PROSC proline synthetase co-transcribed homolog (bacterial)
RPA3 replication protein A3, 14kDa
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SMC4 structural maintenance of chromosomes 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
TFB2M transcription factor B2, mitochondrial
TIPIN TIMELESS interacting protein
TRIB2 tribbles pseudokinase 2