BRD-A21584801_brivanib_BT20_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-A21584801_brivanib_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ALCAM activated leukocyte cell adhesion molecule
BCL2 B-cell CLL/lymphoma 2
BEX1 brain expressed, X-linked 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CHGB chromogranin B
CST1 cystatin SN
CTSE cathepsin E
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR24 24-dehydrocholesterol reductase
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KLF5 Kruppel-like factor 5 (intestinal)
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NEFL neurofilament, light polypeptide
PGC progastricsin (pepsinogen C)
PLXNA2 plexin A2
PNMA2 paraneoplastic Ma antigen 2
PRDX2 peroxiredoxin 2
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS4 regulator of G-protein signaling 4
SCG2 secretogranin II
SCG5 secretogranin V
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TSPAN3 tetraspanin 3

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
BLNK B-cell linker
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLDN3 claudin 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYAB crystallin, alpha B
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFHD1 EF-hand domain family, member D1
ELF5 E74-like factor 5 (ets domain transcription factor)
FABP7 fatty acid binding protein 7, brain
FAS Fas cell surface death receptor
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRB14 growth factor receptor-bound protein 14
IGFBP5 insulin-like growth factor binding protein 5
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MCAM melanoma cell adhesion molecule
MKNK1 MAP kinase interacting serine/threonine kinase 1
NDRG2 NDRG family member 2
NOTCH3 notch 3
PFKP phosphofructokinase, platelet
PFN2 profilin 2
PIP prolactin-induced protein
PRKCD protein kinase C, delta
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRPX sushi-repeat containing protein, X-linked
TBX2 T-box 2
TPD52L1 tumor protein D52-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1