BRD-A21584801_brivanib_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-A21584801_brivanib_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADA adenosine deaminase
ANXA4 annexin A4
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
BAG2 BCL2-associated athanogene 2
BAX BCL2-associated X protein
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DUSP14 dual specificity phosphatase 14
EAPP E2F-associated phosphoprotein
EMX2 empty spiracles homeobox 2
FAM134B family with sequence similarity 134, member B
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FRY furry homolog (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GDF15 growth differentiation factor 15
GRB10 growth factor receptor-bound protein 10
HILPDA hypoxia inducible lipid droplet-associated
HOXB2 homeobox B2
IER5 immediate early response 5
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
INPP1 inositol polyphosphate-1-phosphatase
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JUND jun D proto-oncogene
LPAR6 lysophosphatidic acid receptor 6
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOTCH1 notch 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PERP PERP, TP53 apoptosis effector
PGF placental growth factor
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLAC8 placenta-specific 8
PLS1 plastin 1
PLXNB2 plexin B2
PNMAL1 paraneoplastic Ma antigen family-like 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAD51C RAD51 paralog C
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS27L ribosomal protein S27-like
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SESN1 sestrin 1
SFN stratifin
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SP100 SP100 nuclear antigen
SP110 SP110 nuclear body protein
STOM stomatin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53I3 tumor protein p53 inducible protein 3
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM22 tripartite motif containing 22
TTC39A tetratricopeptide repeat domain 39A
ZBTB20 zinc finger and BTB domain containing 20
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ATF5 activating transcription factor 5
ATMIN ATM interactor
CCND1 cyclin D1
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL6A2 collagen, type VI, alpha 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
DLK1 delta-like 1 homolog (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF5 eukaryotic translation initiation factor 5
F3 coagulation factor III (thromboplastin, tissue factor)
FAM171A1 family with sequence similarity 171, member A1
GLUL glutamate-ammonia ligase
HADH hydroxyacyl-CoA dehydrogenase
HIST1H2BK histone cluster 1, H2bk
HMGA2 high mobility group AT-hook 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IRS2 insulin receptor substrate 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF5B kinesin family member 5B
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LMNB2 lamin B2
LMO4 LIM domain only 4
LPAR1 lysophosphatidic acid receptor 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP9 matrix metallopeptidase 9
MSH6 mutS homolog 6
MSLN mesothelin
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYOF myoferlin
NQO1 NAD(P)H dehydrogenase, quinone 1
OAT ornithine aminotransferase
OSBPL1A oxysterol binding protein-like 1A
PDZD8 PDZ domain containing 8
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PPAP2C phosphatidic acid phosphatase type 2C
RAB13 RAB13, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RBM3 RNA binding motif (RNP1, RRM) protein 3
SMC4 structural maintenance of chromosomes 4
SPTAN1 spectrin, alpha, non-erythrocytic 1
SYT1 synaptotagmin I
WBP5 WW domain binding protein 5