BRD-A21406558_NCGC00229595-01_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-A21406558_NCGC00229595-01_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
C1ORF115 chromosome 1 open reading frame 115
C3 complement component 3
CLU clusterin
COL5A1 collagen, type V, alpha 1
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FKBP11 FK506 binding protein 11, 19 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
HSPA1A heat shock 70kDa protein 1A
IFITM1 interferon induced transmembrane protein 1
IGFBP4 insulin-like growth factor binding protein 4
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IRF8 interferon regulatory factor 8
KRT17 keratin 17, type I
KYNU kynureninase
LUM lumican
LYPD3 LY6/PLAUR domain containing 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRAME preferentially expressed antigen in melanoma
PTGDS prostaglandin D2 synthase 21kDa (brain)
S100A9 S100 calcium binding protein A9
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SRGN serglycin
TPD52L1 tumor protein D52-like 1
TRPS1 trichorhinophalangeal syndrome I
TUBA1A tubulin, alpha 1a
UGDH UDP-glucose 6-dehydrogenase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AUTS2 autism susceptibility candidate 2
CEMIP cell migration inducing protein, hyaluronan binding
CLIC4 chloride intracellular channel 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
E2F2 E2F transcription factor 2
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
KRAS Kirsten rat sarcoma viral oncogene homolog
PTX3 pentraxin 3, long
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
THBS1 thrombospondin 1