BRD-A20697603_T8902_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

258 genes differentially expressed following the BRD-A20697603_T8902_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAM17 ADAM metallopeptidase domain 17
ADGRL2 adhesion G protein-coupled receptor L2
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
AKAP8 A kinase (PRKA) anchor protein 8
AKAP8L A kinase (PRKA) anchor protein 8-like
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BLVRB biliverdin reductase B
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CA1 carbonic anhydrase I
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CD177 CD177 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL1A1 collagen, type I, alpha 1
CTH cystathionine gamma-lyase
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FASTKD5 FAST kinase domains 5
FOS FBJ murine osteosarcoma viral oncogene homolog
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GLA galactosidase, alpha
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPR183 G protein-coupled receptor 183
GTF2B general transcription factor IIB
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
INSR insulin receptor
IRF7 interferon regulatory factor 7
ITM2C integral membrane protein 2C
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KIAA0907 KIAA0907
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
MAGEA1 melanoma antigen family A1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NXF1 nuclear RNA export factor 1
OSER1 oxidative stress responsive serine-rich 1
P3H2 prolyl 3-hydroxylase 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PEG3 paternally expressed 3
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
SELE selectin E
SERINC1 serine incorporator 1
SERINC5 serine incorporator 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMIM7 small integral membrane protein 7
SQSTM1 sequestosome 1
SRGN serglycin
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TCF4 transcription factor 4
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSPYL2 TSPY-like 2
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UGDH UDP-glucose 6-dehydrogenase
WT1 Wilms tumor 1
YPEL5 yippee-like 5 (Drosophila)
YY1AP1 YY1 associated protein 1
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331
ZNF394 zinc finger protein 394

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACP6 acid phosphatase 6, lysophosphatidic
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK2 AHNAK nucleoprotein 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASPH aspartate beta-hydroxylase
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
COG2 component of oligomeric golgi complex 2
COG4 component of oligomeric golgi complex 4
COL1A2 collagen, type I, alpha 2
CPNE1 copine I
CRIP2 cysteine-rich protein 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP4 dual specificity phosphatase 4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETFB electron-transfer-flavoprotein, beta polypeptide
FAM216A family with sequence similarity 216, member A
FBP1 fructose-1,6-bisphosphatase 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKBP1A FK506 binding protein 1A, 12kDa
FSTL1 follistatin-like 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GMDS GDP-mannose 4,6-dehydratase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAPTM4B lysosomal protein transmembrane 4 beta
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL1 lysyl oxidase-like 1
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
METRN meteorin, glial cell differentiation regulator
MLPH melanophilin
MMD monocyte to macrophage differentiation-associated
MRPS33 mitochondrial ribosomal protein S33
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
NBN nibrin
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
NUDCD3 NudC domain containing 3
OSBPL3 oxysterol binding protein-like 3
OXLD1 oxidoreductase-like domain containing 1
PBK PDZ binding kinase
PGM1 phosphoglucomutase 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PON2 paraoxonase 2
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRR7 proline rich 7 (synaptic)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFF3 trefoil factor 3 (intestinal)
TMEM47 transmembrane protein 47
TMPO thymopoietin
TNC tenascin C
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN4 tetraspanin 4
TSTA3 tissue specific transplantation antigen P35B
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E3 ubiquitin-conjugating enzyme E2E 3