BRD-A20697603_T8902_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

321 genes differentially expressed following the BRD-A20697603_T8902_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAM17 ADAM metallopeptidase domain 17
ADGRL2 adhesion G protein-coupled receptor L2
ADM adrenomedullin
ANKRD11 ankyrin repeat domain 11
ANXA1 annexin A1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
AZU1 azurocidin 1
BTG3 BTG family, member 3
CA1 carbonic anhydrase I
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CD163 CD163 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLEC3B C-type lectin domain family 3, member B
CLIC5 chloride intracellular channel 5
COL6A2 collagen, type VI, alpha 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FZD10 frizzled class receptor 10
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBB hemoglobin, beta
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HOXA5 homeobox A5
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL13RA2 interleukin 13 receptor, alpha 2
JAG1 jagged 1
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LAMP1 lysosomal-associated membrane protein 1
LARP6 La ribonucleoprotein domain family, member 6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSX1 msh homeobox 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCB2 nucleobindin 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDIA6 protein disulfide isomerase family A, member 6
PERP PERP, TP53 apoptosis effector
PLIN2 perilipin 2
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRTN3 proteinase 3
PTN pleiotrophin
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM7 small integral membrane protein 7
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
SRGN serglycin
SST somatostatin
STX1A syntaxin 1A (brain)
TDP2 tyrosyl-DNA phosphodiesterase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ABLIM1 actin binding LIM protein 1
ACACB acetyl-CoA carboxylase beta
ACAT1 acetyl-CoA acetyltransferase 1
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AK4 adenylate kinase 4
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AMDHD2 amidohydrolase domain containing 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA9 annexin A9
ARF6 ADP-ribosylation factor 6
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C21ORF33 chromosome 21 open reading frame 33
CA12 carbonic anhydrase XII
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBR4 carbonyl reductase 4
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPM centromere protein M
CIRBP cold inducible RNA binding protein
COL18A1 collagen, type XVIII, alpha 1
CRIP2 cysteine-rich protein 2
CTSH cathepsin H
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCXR dicarbonyl/L-xylulose reductase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
ESRP2 epithelial splicing regulatory protein 2
ETFB electron-transfer-flavoprotein, beta polypeptide
EVL Enah/Vasp-like
F12 coagulation factor XII (Hageman factor)
FAM63A family with sequence similarity 63, member A
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FBP1 fructose-1,6-bisphosphatase 1
FLNB filamin B, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GCAT glycine C-acetyltransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2H5 general transcription factor IIH, polypeptide 5
GTSE1 G-2 and S-phase expressed 1
H1F0 H1 histone family, member 0
HADH hydroxyacyl-CoA dehydrogenase
HAUS4 HAUS augmin-like complex, subunit 4
HIST1H4C histone cluster 1, H4c
HIST3H2A histone cluster 3, H2a
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLTF helicase-like transcription factor
HMG20B high mobility group 20B
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HSPG2 heparan sulfate proteoglycan 2
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITPK1 inositol-tetrakisphosphate 1-kinase
KDM4B lysine (K)-specific demethylase 4B
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTBP3 latent transforming growth factor beta binding protein 3
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MGMT O-6-methylguanine-DNA methyltransferase
MKI67 marker of proliferation Ki-67
MLPH melanophilin
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MXRA7 matrix-remodelling associated 7
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NFIB nuclear factor I/B
NHP2 NHP2 ribonucleoprotein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY1R neuropeptide Y receptor Y1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP210 nucleoporin 210kDa
OLFM1 olfactomedin 1
OXLD1 oxidoreductase-like domain containing 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKL phosphofructokinase, liver
PLA2G16 phospholipase A2, group XVI
PLIN1 perilipin 1
PLK1 polo-like kinase 1
PNKP polynucleotide kinase 3'-phosphatase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PTMA prothymosin, alpha
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCARD PYD and CARD domain containing
RAB31 RAB31, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM47 RNA binding motif protein 47
RFC2 replication factor C (activator 1) 2, 40kDa
RGS5 regulator of G-protein signaling 5
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RUVBL2 RuvB-like AAA ATPase 2
SEPT9 septin 9
SEPW1 selenoprotein W, 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SREBF1 sterol regulatory element binding transcription factor 1
SRM spermidine synthase
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNGR2 synaptogyrin 2
SYT1 synaptotagmin I
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D16 TBC1 domain family, member 16
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TK1 thymidine kinase 1, soluble
TM7SF2 transmembrane 7 superfamily member 2
TMEM106C transmembrane protein 106C
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPGS2 tubulin polyglutamylase complex subunit 2
TPM1 tropomyosin 1 (alpha)
TRIOBP TRIO and F-actin binding protein
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TUBG1 tubulin, gamma 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
VCAN versican
WDR61 WD repeat domain 61
ZNF185 zinc finger protein 185 (LIM domain)