BRD-A20697603_T8902_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

345 genes differentially expressed following the BRD-A20697603_T8902_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADAM17 ADAM metallopeptidase domain 17
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BAG3 BCL2-associated athanogene 3
BMP7 bone morphogenetic protein 7
BRAP BRCA1 associated protein
BTG3 BTG family, member 3
C18ORF8 chromosome 18 open reading frame 8
CA2 carbonic anhydrase II
CAB39 calcium binding protein 39
CALCA calcitonin-related polypeptide alpha
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL2A1 collagen, type II, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EZR ezrin
FAF2 Fas associated factor family member 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GCH1 GTP cyclohydrolase 1
GLA galactosidase, alpha
GOLT1B golgi transport 1B
GPRC5C G protein-coupled receptor, class C, group 5, member C
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCCS holocytochrome c synthase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IL1R2 interleukin 1 receptor, type II
KLHL21 kelch-like family member 21
LAMB3 laminin, beta 3
LHFPL2 lipoma HMGIC fusion partner-like 2
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MKRN1 makorin ring finger protein 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MRPL49 mitochondrial ribosomal protein L49
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NUP98 nucleoporin 98kDa
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDGFA platelet-derived growth factor alpha polypeptide
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
RAE1 ribonucleic acid export 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RB1CC1 RB1-inducible coiled-coil 1
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SEC24A SEC24 family member A
SERINC5 serine incorporator 5
SIK3 SIK family kinase 3
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM7 small integral membrane protein 7
SOWAHC sosondowah ankyrin repeat domain family member C
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
STX3 syntaxin 3
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBP TATA box binding protein
TCP1 t-complex 1
TERF2IP telomeric repeat binding factor 2, interacting protein
TEX10 testis expressed 10
TMEM41B transmembrane protein 41B
TMEM57 transmembrane protein 57
TNC tenascin C
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TRIM36 tripartite motif containing 36
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL1 thioredoxin-like 1
TXNL4B thioredoxin-like 4B
UBXN7 UBX domain protein 7
UFD1L ubiquitin fusion degradation 1 like (yeast)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP47 ubiquitin specific peptidase 47
WIF1 WNT inhibitory factor 1
ZBTB11 zinc finger and BTB domain containing 11
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACO1 aconitase 1, soluble
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGRN agrin
AGTR1 angiotensin II receptor, type 1
AK4 adenylate kinase 4
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
APMAP adipocyte plasma membrane associated protein
APOLD1 apolipoprotein L domain containing 1
ASPH aspartate beta-hydroxylase
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C10ORF10 chromosome 10 open reading frame 10
C21ORF33 chromosome 21 open reading frame 33
C3 complement component 3
CA9 carbonic anhydrase IX
CALB2 calbindin 2
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CFD complement factor D (adipsin)
CHMP4A charged multivesicular body protein 4A
CIDEA cell death-inducing DFFA-like effector a
CKB creatine kinase, brain
COA3 cytochrome c oxidase assembly factor 3
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CTBP1 C-terminal binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYBA cytochrome b-245, alpha polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLC1 DLC1 Rho GTPase activating protein
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
EBP emopamil binding protein (sterol isomerase)
ECI1 enoyl-CoA delta isomerase 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHBP1 EH domain binding protein 1
EHD2 EH-domain containing 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
FAM13A family with sequence similarity 13, member A
FASN fatty acid synthase
FBN1 fibrillin 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FPGS folylpolyglutamate synthase
FST follistatin
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
GAS1 growth arrest-specific 1
GHR growth hormone receptor
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GPI glucose-6-phosphate isomerase
GPX1 glutathione peroxidase 1
GYG2 glycogenin 2
HADH hydroxyacyl-CoA dehydrogenase
HEG1 heart development protein with EGF-like domains 1
HILPDA hypoxia inducible lipid droplet-associated
HSDL2 hydroxysteroid dehydrogenase like 2
HSPG2 heparan sulfate proteoglycan 2
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
ITGA7 integrin, alpha 7
ITGB1BP1 integrin beta 1 binding protein 1
ITGB5 integrin, beta 5
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEP leptin
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHFP lipoma HMGIC fusion partner
LOXL1 lysyl oxidase-like 1
LOXL2 lysyl oxidase-like 2
LPL lipoprotein lipase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MARC1 mitochondrial amidoxime reducing component 1
MARCKSL1 MARCKS-like 1
MEST mesoderm specific transcript
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MSLN mesothelin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC16 mucin 16, cell surface associated
MXRA7 matrix-remodelling associated 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NMU neuromedin U
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFC platelet derived growth factor C
PECR peroxisomal trans-2-enoyl-CoA reductase
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKL phosphofructokinase, liver
PGM1 phosphoglucomutase 1
PGRMC2 progesterone receptor membrane component 2
PLA2G16 phospholipase A2, group XVI
PLIN1 perilipin 1
PLXNB2 plexin B2
PLXND1 plexin D1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PON2 paraoxonase 2
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTRF polymerase I and transcript release factor
PTTG1 pituitary tumor-transforming 1
PTX3 pentraxin 3, long
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCARD PYD and CARD domain containing
PYGL phosphorylase, glycogen, liver
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT11 septin 11
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A10 solute carrier family 38, member 10
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STS steroid sulfatase (microsomal), isozyme S
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
TCEAL4 transcription elongation factor A (SII)-like 4
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP4 TIMP metallopeptidase inhibitor 4
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TMEM14B transmembrane protein 14B
TMEM47 transmembrane protein 47
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TSKU tsukushi, small leucine rich proteoglycan
TSPAN4 tetraspanin 4
TSPO translocator protein (18kDa)
TST thiosulfate sulfurtransferase (rhodanese)
TUBB6 tubulin, beta 6 class V
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
VEGFA vascular endothelial growth factor A