BRD-A20697603_598226_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

324 genes differentially expressed following the BRD-A20697603_598226_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATG101 autophagy related 101
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BAG3 BCL2-associated athanogene 3
BCAS2 breast carcinoma amplified sequence 2
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
BRAP BRCA1 associated protein
CACYBP calcyclin binding protein
CBR3 carbonyl reductase 3
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CRABP1 cellular retinoic acid binding protein 1
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EAPP E2F-associated phosphoprotein
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GAREM GRB2 associated, regulator of MAPK1
GCH1 GTP cyclohydrolase 1
GLA galactosidase, alpha
HMOX1 heme oxygenase 1
HP haptoglobin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGHMBP2 immunoglobulin mu binding protein 2
IL6R interleukin 6 receptor
IQCG IQ motif containing G
JMJD6 jumonji domain containing 6
KDM2A lysine (K)-specific demethylase 2A
LEF1 lymphoid enhancer-binding factor 1
LYPD1 LY6/PLAUR domain containing 1
MECOM MDS1 and EVI1 complex locus
MRPL18 mitochondrial ribosomal protein L18
MSX1 msh homeobox 1
NOSIP nitric oxide synthase interacting protein
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
PGRMC1 progesterone receptor membrane component 1
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RAD9A RAD9 homolog A (S. pombe)
RAE1 ribonucleic acid export 1
RNMT RNA (guanine-7-) methyltransferase
RRAGC Ras-related GTP binding C
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
RUNX3 runt-related transcription factor 3
SEC24A SEC24 family member A
SEPT6 septin 6
SIX2 SIX homeobox 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNX11 sorting nexin 11
SOWAHC sosondowah ankyrin repeat domain family member C
STIP1 stress-induced phosphoprotein 1
TCP1 t-complex 1
TEX10 testis expressed 10
TMCO1 transmembrane and coiled-coil domains 1
TNPO1 transportin 1
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TXNL1 thioredoxin-like 1
TXNL4B thioredoxin-like 4B
UFD1L ubiquitin fusion degradation 1 like (yeast)
USP47 ubiquitin specific peptidase 47
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF394 zinc finger protein 394

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ADAM10 ADAM metallopeptidase domain 10
ADARB1 adenosine deaminase, RNA-specific, B1
ADCY1 adenylate cyclase 1 (brain)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGRN agrin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMOTL2 angiomotin like 2
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
ANXA4 annexin A4
ANXA6 annexin A6
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ASPH aspartate beta-hydroxylase
C3 complement component 3
CADPS2 Ca++-dependent secretion activator 2
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASQ2 calsequestrin 2 (cardiac muscle)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CHMP4A charged multivesicular body protein 4A
CKM creatine kinase, muscle
CLIC4 chloride intracellular channel 4
CMC4 C-x(9)-C motif containing 4
COL15A1 collagen, type XV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL5A2 collagen, type V, alpha 2
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPNE1 copine I
CSTA cystatin A (stefin A)
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYR61 cysteine-rich, angiogenic inducer, 61
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DES desmin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHBP1 EH domain binding protein 1
EHD2 EH-domain containing 2
ENO3 enolase 3 (beta, muscle)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETFB electron-transfer-flavoprotein, beta polypeptide
EVL Enah/Vasp-like
FAM127A family with sequence similarity 127, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBN1 fibrillin 1
FHL1 four and a half LIM domains 1
FRY furry homolog (Drosophila)
GAA glucosidase, alpha; acid
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAMT guanidinoacetate N-methyltransferase
GDF15 growth differentiation factor 15
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
H1FX H1 histone family, member X
HACD1 3-hydroxyacyl-CoA dehydratase 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HEG1 heart development protein with EGF-like domains 1
HMGB3 high mobility group box 3
HMGN4 high mobility group nucleosomal binding domain 4
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPB2 heat shock 27kDa protein 2
HSPB3 heat shock 27kDa protein 3
HSPG2 heparan sulfate proteoglycan 2
ICMT isoprenylcysteine carboxyl methyltransferase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL32 interleukin 32
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KANK2 KN motif and ankyrin repeat domains 2
KLHDC2 kelch domain containing 2
KLHL41 kelch-like family member 41
KRCC1 lysine-rich coiled-coil 1
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LMCD1 LIM and cysteine-rich domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LTBP2 latent transforming growth factor beta binding protein 2
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MACF1 microtubule-actin crosslinking factor 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MARCKSL1 MARCKS-like 1
MB myoglobin
MEF2C myocyte enhancer factor 2C
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MGP matrix Gla protein
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYH11 myosin, heavy chain 11, smooth muscle
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
MYOF myoferlin
MYOZ2 myozenin 2
NAV2 neuron navigator 2
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NEB nebulin
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID2 nidogen 2 (osteonidogen)
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OLFM4 olfactomedin 4
OPN3 opsin 3
PDGFC platelet derived growth factor C
PDLIM3 PDZ and LIM domain 3
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLS3 plastin 3
PLSCR4 phospholipid scramblase 4
PLXND1 plexin D1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRELP proline/arginine-rich end leucine-rich repeat protein
PREPL prolyl endopeptidase-like
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRSS23 protease, serine, 23
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTX3 pentraxin 3, long
PYCARD PYD and CARD domain containing
PYGB phosphorylase, glycogen; brain
PYGL phosphorylase, glycogen, liver
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
RRM2 ribonucleotide reductase M2
RYR1 ryanodine receptor 1 (skeletal)
S100A13 S100 calcium binding protein A13
S100A4 S100 calcium binding protein A4
SCAND1 SCAN domain containing 1
SDPR serum deprivation response
SEPT11 septin 11
SFRP1 secreted frizzled-related protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC35E2B solute carrier family 35, member E2B
SLC38A10 solute carrier family 38, member 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN1 stathmin 1
STS steroid sulfatase (microsomal), isozyme S
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
SVIL supervillin
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCEAL4 transcription elongation factor A (SII)-like 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMEM230 transmembrane protein 230
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TNNC1 troponin C type 1 (slow)
TNNC2 troponin C type 2 (fast)
TNNI1 troponin I type 1 (skeletal, slow)
TNNI2 troponin I type 2 (skeletal, fast)
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRAM2 translocation associated membrane protein 2
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TSPAN12 tetraspanin 12
TSPAN4 tetraspanin 4
TST thiosulfate sulfurtransferase (rhodanese)
TTN titin
UGP2 UDP-glucose pyrophosphorylase 2
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VCAN versican
WDR13 WD repeat domain 13
WWTR1 WW domain containing transcription regulator 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF185 zinc finger protein 185 (LIM domain)