BRD-A20697603_598226_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-A20697603_598226_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACSL3 acyl-CoA synthetase long-chain family member 3
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
APOD apolipoprotein D
ATF3 activating transcription factor 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
C3 complement component 3
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAMP cathelicidin antimicrobial peptide
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
DEFA4 defensin, alpha 4, corticostatin
DPT dermatopontin
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FXYD6 FXYD domain containing ion transport regulator 6
GLUL glutamate-ammonia ligase
GSTA1 glutathione S-transferase alpha 1
GUSBP3 glucuronidase, beta pseudogene 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSIG1 insulin induced gene 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KLHL24 kelch-like family member 24
LGALS4 lectin, galactoside-binding, soluble, 4
LYZ lysozyme
MAOB monoamine oxidase B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPO myeloperoxidase
MSMB microseminoprotein, beta-
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
OSBPL1A oxysterol binding protein-like 1A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PRDX6 peroxiredoxin 6
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN2 reticulon 2
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SHB Src homology 2 domain containing adaptor protein B
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SPARCL1 SPARC-like 1 (hevin)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SST somatostatin
TBPL1 TBP-like 1
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AK1 adenylate kinase 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ASXL2 additional sex combs like transcriptional regulator 2
ATF5 activating transcription factor 5
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
AURKB aurora kinase B
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
C9ORF3 chromosome 9 open reading frame 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25B cell division cycle 25B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHMP6 charged multivesicular body protein 6
CSE1L CSE1 chromosome segregation 1-like (yeast)
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EMP3 epithelial membrane protein 3
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM208A family with sequence similarity 208, member A
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
HOXC10 homeobox C10
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGLV2-23 immunoglobulin lambda variable 2-23
JADE2 jade family PHD finger 2
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
KRT7 keratin 7, type II
LACTB2 lactamase, beta 2
LAMC2 laminin, gamma 2
LMNB2 lamin B2
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
NAV2 neuron navigator 2
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NT5DC2 5'-nucleotidase domain containing 2
NUP62 nucleoporin 62kDa
PAX8 paired box 8
PDS5A PDS5 cohesin associated factor A
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRKCA protein kinase C, alpha
PRSS2 protease, serine, 2 (trypsin 2)
RAB31 RAB31, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
S100A2 S100 calcium binding protein A2
SEPT8 septin 8
SLPI secretory leukocyte peptidase inhibitor
SPDL1 spindle apparatus coiled-coil protein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STXBP1 syntaxin binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAK2 trafficking protein, kinesin binding 2
UPK1B uroplakin 1B
ZMIZ1 zinc finger, MIZ-type containing 1