BRD-A20697603_598226_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

297 genes differentially expressed following the BRD-A20697603_598226_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKAP8L A kinase (PRKA) anchor protein 8-like
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BMP7 bone morphogenetic protein 7
BTG3 BTG family, member 3
C18ORF8 chromosome 18 open reading frame 8
CA2 carbonic anhydrase II
CBR3 carbonyl reductase 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK4 dedicator of cytokinesis 4
DUSP3 dual specificity phosphatase 3
EMC3 ER membrane protein complex subunit 3
FOXG1 forkhead box G1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GLA galactosidase, alpha
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
JMJD6 jumonji domain containing 6
KCTD5 potassium channel tetramerization domain containing 5
LARP4 La ribonucleoprotein domain family, member 4
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAGEB2 melanoma antigen family B2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
NCAM1 neural cell adhesion molecule 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDGFA platelet-derived growth factor alpha polypeptide
PELO pelota homolog (Drosophila)
PNP purine nucleoside phosphorylase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSEN1 presenilin 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSME4 proteasome (prosome, macropain) activator subunit 4
RAE1 ribonucleic acid export 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RB1CC1 RB1-inducible coiled-coil 1
RIOK3 RIO kinase 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SEC24A SEC24 family member A
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM7 small integral membrane protein 7
SNX11 sorting nexin 11
SOWAHC sosondowah ankyrin repeat domain family member C
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
STIP1 stress-induced phosphoprotein 1
TERF2IP telomeric repeat binding factor 2, interacting protein
TEX10 testis expressed 10
THUMPD1 THUMP domain containing 1
TM9SF2 transmembrane 9 superfamily member 2
TMEM255A transmembrane protein 255A
TMEM57 transmembrane protein 57
TRIM36 tripartite motif containing 36
TUBB2A tubulin, beta 2A class IIa
TXNL1 thioredoxin-like 1
UBE2B ubiquitin-conjugating enzyme E2B
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UBXN7 UBX domain protein 7
UFD1L ubiquitin fusion degradation 1 like (yeast)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
ZNF394 zinc finger protein 394
ZNF410 zinc finger protein 410

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ACAT1 acetyl-CoA acetyltransferase 1
ACLY ATP citrate lyase
ACO1 aconitase 1, soluble
ACSL1 acyl-CoA synthetase long-chain family member 1
ADA adenosine deaminase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADARB1 adenosine deaminase, RNA-specific, B1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGTR1 angiotensin II receptor, type 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
APMAP adipocyte plasma membrane associated protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPH aspartate beta-hydroxylase
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C21ORF33 chromosome 21 open reading frame 33
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
CA9 carbonic anhydrase IX
CALB2 calbindin 2
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPF centromere protein F, 350/400kDa
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
CIDEA cell death-inducing DFFA-like effector a
CIDEC cell death-inducing DFFA-like effector c
CIRBP cold inducible RNA binding protein
COL18A1 collagen, type XVIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPM carboxypeptidase M
CST7 cystatin F (leukocystatin)
CTBP1 C-terminal binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DLC1 DLC1 Rho GTPase activating protein
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYSL2 dihydropyrimidinase-like 2
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHBP1 EH domain binding protein 1
EHD2 EH-domain containing 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS2 fatty acid desaturase 2
FAM127A family with sequence similarity 127, member A
FAM13A family with sequence similarity 13, member A
FAM162A family with sequence similarity 162, member A
FAR2 fatty acyl CoA reductase 2
FASN fatty acid synthase
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
G0S2 G0/G1 switch 2
GHR growth hormone receptor
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GPX1 glutathione peroxidase 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
GYG2 glycogenin 2
HADH hydroxyacyl-CoA dehydrogenase
HILPDA hypoxia inducible lipid droplet-associated
HOOK2 hook microtubule-tethering protein 2
HSDL2 hydroxysteroid dehydrogenase like 2
ICAM1 intercellular adhesion molecule 1
IFITM2 interferon induced transmembrane protein 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
ITGA7 integrin, alpha 7
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDHB lactate dehydrogenase B
LEP leptin
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
LOXL1 lysyl oxidase-like 1
LPL lipoprotein lipase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTF lactotransferrin
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MARC1 mitochondrial amidoxime reducing component 1
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MSRB2 methionine sulfoxide reductase B2
MYLK myosin light chain kinase
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NISCH nischarin
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NREP neuronal regeneration related protein
NTS neurotensin
PDLIM2 PDZ and LIM domain 2 (mystique)
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEBP1 phosphatidylethanolamine binding protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKL phosphofructokinase, liver
PGRMC2 progesterone receptor membrane component 2
PLIN1 perilipin 1
PLSCR4 phospholipid scramblase 4
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PON2 paraoxonase 2
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCARD PYD and CARD domain containing
PYGL phosphorylase, glycogen, liver
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
RHOB ras homolog family member B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SEPT11 septin 11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A10 solute carrier family 38, member 10
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STS steroid sulfatase (microsomal), isozyme S
THBS1 thrombospondin 1
TIMP4 TIMP metallopeptidase inhibitor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TNS3 tensin 3
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TSPAN4 tetraspanin 4
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
XYLT1 xylosyltransferase I