BRD-A20589515_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-A20589515_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ARHGAP29 Rho GTPase activating protein 29
BASP1 brain abundant, membrane attached signal protein 1
CADM1 cell adhesion molecule 1
CCL19 chemokine (C-C motif) ligand 19
CD163 CD163 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEP57 centrosomal protein 57kDa
CHGB chromogranin B
CTSZ cathepsin Z
CXCL12 chemokine (C-X-C motif) ligand 12
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
G0S2 G0/G1 switch 2
GCH1 GTP cyclohydrolase 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOPX HOP homeobox
ITM2A integral membrane protein 2A
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MSN moesin
NPR3 natriuretic peptide receptor 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PEG3 paternally expressed 3
PLIN2 perilipin 2
PLXNC1 plexin C1
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
QPCT glutaminyl-peptide cyclotransferase
RBKS ribokinase
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TFEC transcription factor EC
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TLE4 transducin-like enhancer of split 4
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALOX5 arachidonate 5-lipoxygenase
AQP3 aquaporin 3 (Gill blood group)
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CD47 CD47 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLCA4 chloride channel accessory 4
CNPY3 canopy FGF signaling regulator 3
CSRP2 cysteine and glycine-rich protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DUOX2 dual oxidase 2
GDF15 growth differentiation factor 15
HCAR3 hydroxycarboxylic acid receptor 3
HMG20B high mobility group 20B
HSPB8 heat shock 22kDa protein 8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
ITGA6 integrin, alpha 6
KRT13 keratin 13, type I
KRT4 keratin 4, type II
LCN2 lipocalin 2
LRRC17 leucine rich repeat containing 17
MFSD10 major facilitator superfamily domain containing 10
MUC4 mucin 4, cell surface associated
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
PLK2 polo-like kinase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RNASET2 ribonuclease T2
STC1 stanniocalcin 1
TMF1 TATA element modulatory factor 1
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8