BRD-A20243730_Danazol_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

253 genes differentially expressed following the BRD-A20243730_Danazol_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAA1 acetyl-CoA acyltransferase 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANO1 anoctamin 1, calcium activated chloride channel
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ANXA3 annexin A3
ANXA5 annexin A5
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARMCX3 armadillo repeat containing, X-linked 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIK BCL2-interacting killer (apoptosis-inducing)
BTG2 BTG family, member 2
CCPG1 cell cycle progression 1
CD177 CD177 molecule
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CKAP4 cytoskeleton-associated protein 4
CLIC5 chloride intracellular channel 5
COBL cordon-bleu WH2 repeat protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CUX2 cut-like homeobox 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EDN3 endothelin 3
ELOVL5 ELOVL fatty acid elongase 5
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FABP4 fatty acid binding protein 4, adipocyte
FAM189A2 family with sequence similarity 189, member A2
FAM63A family with sequence similarity 63, member A
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GADD45B growth arrest and DNA-damage-inducible, beta
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
GPER1 G protein-coupled estrogen receptor 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HGD homogentisate 1,2-dioxygenase
HSPA2 heat shock 70kDa protein 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IL1R1 interleukin 1 receptor, type I
INPP1 inositol polyphosphate-1-phosphatase
IRS1 insulin receptor substrate 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KDM4B lysine (K)-specific demethylase 4B
KIAA1324 KIAA1324
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LGMN legumain
LINC00341 long intergenic non-protein coding RNA 341
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MNDA myeloid cell nuclear differentiation antigen
MSMB microseminoprotein, beta-
MSX1 msh homeobox 1
MT1M metallothionein 1M
MYO5C myosin VC
NAGK N-acetylglucosamine kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
PGM3 phosphoglucomutase 3
PLIN3 perilipin 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRKCD protein kinase C, delta
PRR15L proline rich 15-like
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC35E3 solute carrier family 35, member E3
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAP23 synaptosomal-associated protein, 23kDa
SOCS2 suppressor of cytokine signaling 2
SPDEF SAM pointed domain containing ETS transcription factor
SPINT1 serine peptidase inhibitor, Kunitz type 1
STXBP2 syntaxin binding protein 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TRPM4 transient receptor potential cation channel, subfamily M, member 4
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CACYBP calcyclin binding protein
CCDC85B coiled-coil domain containing 85B
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CCNF cyclin F
CD81 CD81 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CXCL14 chemokine (C-X-C motif) ligand 14
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
F8 coagulation factor VIII, procoagulant component
FAM46A family with sequence similarity 46, member A
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FAS Fas cell surface death receptor
FBL fibrillarin
GAS6 growth arrest-specific 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLGA8A golgin A8 family, member A
H3F3B H3 histone, family 3B (H3.3B)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL33 interleukin 33
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIF15 kinesin family member 15
KIF2C kinesin family member 2C
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MRPS30 mitochondrial ribosomal protein S30
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NCAPH non-SMC condensin I complex, subunit H
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUSAP1 nucleolar and spindle associated protein 1
ORC6 origin recognition complex, subunit 6
OXCT1 3-oxoacid CoA transferase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAIP1 poly(A) binding protein interacting protein 1
PCNA proliferating cell nuclear antigen
PCYOX1L prenylcysteine oxidase 1 like
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLR1E polymerase (RNA) I polypeptide E, 53kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
PRDX2 peroxiredoxin 2
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRR7 proline rich 7 (synaptic)
PTTG1 pituitary tumor-transforming 1
RAD54L RAD54-like (S. cerevisiae)
RANBP1 RAN binding protein 1
RBBP8 retinoblastoma binding protein 8
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RNASEH2A ribonuclease H2, subunit A
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RRM1 ribonucleotide reductase M1
RUFY3 RUN and FYVE domain containing 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SF3A3 splicing factor 3a, subunit 3, 60kDa
SIGMAR1 sigma non-opioid intracellular receptor 1
SRSF7 serine/arginine-rich splicing factor 7
ST7 suppression of tumorigenicity 7
TACC3 transforming, acidic coiled-coil containing protein 3
TES testin LIM domain protein
TMEM97 transmembrane protein 97
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRAP1 TNF receptor-associated protein 1
TRIB1 tribbles pseudokinase 1
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A