BRD-A20243730_Danazol_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-A20243730_Danazol_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ARMCX2 armadillo repeat containing, X-linked 2
BAX BCL2-associated X protein
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BPHL biphenyl hydrolase-like (serine hydrolase)
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CD300A CD300a molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COG7 component of oligomeric golgi complex 7
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EXT1 exostosin glycosyltransferase 1
FLT1 fms-related tyrosine kinase 1
GMPR guanosine monophosphate reductase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GRB7 growth factor receptor-bound protein 7
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-F major histocompatibility complex, class I, F
IFI16 interferon, gamma-inducible protein 16
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1RN interleukin 1 receptor antagonist
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP3 lysosomal-associated membrane protein 3
LDOC1 leucine zipper, down-regulated in cancer 1
LPAR6 lysophosphatidic acid receptor 6
LSR lipolysis stimulated lipoprotein receptor
LY6E lymphocyte antigen 6 complex, locus E
LYN LYN proto-oncogene, Src family tyrosine kinase
MDK midkine (neurite growth-promoting factor 2)
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCF2 neutrophil cytosolic factor 2
NEB nebulin
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NVL nuclear VCP-like
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMM2 phosphomannomutase 2
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTN pleiotrophin
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PXDN peroxidasin
RAB27A RAB27A, member RAS oncogene family
RAD21 RAD21 homolog (S. pombe)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SHB Src homology 2 domain containing adaptor protein B
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX17 SRY (sex determining region Y)-box 17
SPON2 spondin 2, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
TESK1 testis-specific kinase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLK2 tousled-like kinase 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TPM4 tropomyosin 4
TUBB6 tubulin, beta 6 class V
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT9 acyl-CoA thioesterase 9
ACSL1 acyl-CoA synthetase long-chain family member 1
ADD3 adducin 3 (gamma)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COMP cartilage oligomeric matrix protein
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR3 early growth response 3
FKBP14 FK506 binding protein 14, 22 kDa
FKBP5 FK506 binding protein 5
GMDS GDP-mannose 4,6-dehydratase
GOLGA8A golgin A8 family, member A
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
IDI1 isopentenyl-diphosphate delta isomerase 1
IL6ST interleukin 6 signal transducer
KIAA0101 KIAA0101
LAMA2 laminin, alpha 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MGP matrix Gla protein
MPO myeloperoxidase
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCYOX1L prenylcysteine oxidase 1 like
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLS3 plastin 3
PTGES prostaglandin E synthase
PURA purine-rich element binding protein A
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
S100A10 S100 calcium binding protein A10
SACS sacsin molecular chaperone
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINK1 serine peptidase inhibitor, Kazal type 1
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TOB1 transducer of ERBB2, 1
TSPAN8 tetraspanin 8
TSPYL1 TSPY-like 1
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZCCHC24 zinc finger, CCHC domain containing 24
ZEB2 zinc finger E-box binding homeobox 2