BRD-A20243730_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-A20243730_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE41 basic helix-loop-helix family, member e41
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP57 centrosomal protein 57kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRISP3 cysteine-rich secretory protein 3
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DOK5 docking protein 5
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FAM129A family with sequence similarity 129, member A
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATAD1 GATA zinc finger domain containing 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
PTX3 pentraxin 3, long
RSL1D1 ribosomal L1 domain containing 1
SAMD4A sterile alpha motif domain containing 4A
SARS seryl-tRNA synthetase
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPP1 secreted phosphoprotein 1
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
TAGLN transgelin
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM47 transmembrane protein 47
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
UFM1 ubiquitin-fold modifier 1
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BST2 bone marrow stromal cell antigen 2
CALR calreticulin
CLCA2 chloride channel accessory 2
CLIC3 chloride intracellular channel 3
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A6 collagen, type IV, alpha 6
CTSV cathepsin V
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FADS2 fatty acid desaturase 2
FBLN1 fibulin 1
FGB fibrinogen beta chain
FXYD3 FXYD domain containing ion transport regulator 3
H1FX H1 histone family, member X
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRF8 interferon regulatory factor 8
KIAA0101 KIAA0101
LBH limb bud and heart development
LGALS1 lectin, galactoside-binding, soluble, 1
LIG1 ligase I, DNA, ATP-dependent
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
MSL1 male-specific lethal 1 homolog (Drosophila)
NDN necdin, melanoma antigen (MAGE) family member
OPN3 opsin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTCH1 patched 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SETBP1 SET binding protein 1
SFRP1 secreted frizzled-related protein 1
SRSF5 serine/arginine-rich splicing factor 5
STMN1 stathmin 1
TMEM97 transmembrane protein 97
VCAN versican