BRD-A20126139_MEDRYSONE_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-A20126139_MEDRYSONE_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ACP2 acid phosphatase 2, lysosomal
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIRF adipogenesis regulatory factor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
CA1 carbonic anhydrase I
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD163 CD163 molecule
CD47 CD47 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHN2 chimerin 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLPTM1 cleft lip and palate associated transmembrane protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYBB cytochrome b-245, beta polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DLX5 distal-less homeobox 5
DUSP4 dual specificity phosphatase 4
ECM1 extracellular matrix protein 1
EDN3 endothelin 3
EML3 echinoderm microtubule associated protein like 3
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
FAM63A family with sequence similarity 63, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FUCA1 fucosidase, alpha-L- 1, tissue
GALC galactosylceramidase
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOMER2 homer scaffolding protein 2
IL1R1 interleukin 1 receptor, type I
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KDM4B lysine (K)-specific demethylase 4B
KIAA1324 KIAA1324
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LGMN legumain
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCL1 myeloid cell leukemia 1
MLPH melanophilin
MSMB microseminoprotein, beta-
MT1M metallothionein 1M
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NKX3-1 NK3 homeobox 1
NUCB2 nucleobindin 2
OAT ornithine aminotransferase
OLFML2A olfactomedin-like 2A
OLFML3 olfactomedin-like 3
PDIA3 protein disulfide isomerase family A, member 3
PGC progastricsin (pepsinogen C)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PSAP prosaposin
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAB4A RAB4A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RUNX1 runt-related transcription factor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SYNM synemin, intermediate filament protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TP53I3 tumor protein p53 inducible protein 3
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DENND1B DENN/MADD domain containing 1B
DIAPH2 diaphanous-related formin 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
ENOPH1 enolase-phosphatase 1
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXL12 F-box and leucine-rich repeat protein 12
GTSE1 G-2 and S-phase expressed 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HES1 hes family bHLH transcription factor 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
ISG15 ISG15 ubiquitin-like modifier
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KLHL23 kelch-like family member 23
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUSAP1 nucleolar and spindle associated protein 1
OXCT1 3-oxoacid CoA transferase 1
PBK PDZ binding kinase
PDZK1IP1 PDZK1 interacting protein 1
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PSAT1 phosphoserine aminotransferase 1
PTTG1 pituitary tumor-transforming 1
RUFY3 RUN and FYVE domain containing 3
SHCBP1 SHC SH2-domain binding protein 1
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
ST7 suppression of tumorigenicity 7
TACC3 transforming, acidic coiled-coil containing protein 3
TEX30 testis expressed 30
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN8 tetraspanin 8
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C