BRD-A20126139_MEDRYSONE_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-A20126139_MEDRYSONE_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
AQP3 aquaporin 3 (Gill blood group)
BCL6 B-cell CLL/lymphoma 6
BPIFA1 BPI fold containing family A, member 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPD carboxypeptidase D
CSTA cystatin A (stefin A)
DMBT1 deleted in malignant brain tumors 1
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
EZR ezrin
FAM65B family with sequence similarity 65, member B
FKBP5 FK506 binding protein 5
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HOMER3 homer scaffolding protein 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KAZN kazrin, periplakin interacting protein
LCN2 lipocalin 2
LOX lysyl oxidase
MAOA monoamine oxidase A
MMP7 matrix metallopeptidase 7
MUC1 mucin 1, cell surface associated
MUC4 mucin 4, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NUTF2 nuclear transport factor 2
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PPL periplakin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RXRA retinoid X receptor, alpha
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SFTPA2 surfactant protein A2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ADIRF adipogenesis regulatory factor
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANO1 anoctamin 1, calcium activated chloride channel
ARL4C ADP-ribosylation factor-like 4C
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD200 CD200 molecule
CD52 CD52 molecule
CD8A CD8a molecule
COL15A1 collagen, type XV, alpha 1
COL9A3 collagen, type IX, alpha 3
CRABP1 cellular retinoic acid binding protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLD dihydrolipoamide dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
ESR1 estrogen receptor 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP4 FK506 binding protein 4, 59kDa
GATA6 GATA binding protein 6
GBP2 guanylate binding protein 2, interferon-inducible
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5B G protein-coupled receptor, class C, group 5, member B
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA1 high mobility group AT-hook 1
HOXB2 homeobox B2
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
ISYNA1 inositol-3-phosphate synthase 1
KIF14 kinesin family member 14
LMO4 LIM domain only 4
LXN latexin
MATN2 matrilin 2
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
MRPL13 mitochondrial ribosomal protein L13
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PALLD palladin, cytoskeletal associated protein
PDZRN3 PDZ domain containing ring finger 3
PHYH phytanoyl-CoA 2-hydroxylase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBP4 retinol binding protein 4, plasma
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SMAD3 SMAD family member 3
TCF4 transcription factor 4
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TMPRSS3 transmembrane protease, serine 3
TPM1 tropomyosin 1 (alpha)
TRPS1 trichorhinophalangeal syndrome I
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VTCN1 V-set domain containing T cell activation inhibitor 1