BRD-A20126139_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-A20126139_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
APOC1 apolipoprotein C-I
ATF3 activating transcription factor 3
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
CAV1 caveolin 1, caveolae protein, 22kDa
CDC42 cell division cycle 42
DDIT4 DNA-damage-inducible transcript 4
EDNRA endothelin receptor type A
EMP1 epithelial membrane protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FERMT2 fermitin family member 2
FKBP5 FK506 binding protein 5
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF5 Kruppel-like factor 5 (intestinal)
KLF9 Kruppel-like factor 9
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS1 lectin, galactoside-binding, soluble, 1
LPL lipoprotein lipase
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
MT1E metallothionein 1E
MX1 MX dynamin-like GTPase 1
NCF2 neutrophil cytosolic factor 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDLIM1 PDZ and LIM domain 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PER1 period circadian clock 1
PPL periplakin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
TMSB15A thymosin beta 15a
TSC22D3 TSC22 domain family, member 3
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
FOSL1 FOS-like antigen 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GRWD1 glutamate-rich WD repeat containing 1
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IKZF1 IKAROS family zinc finger 1 (Ikaros)
MAST4 microtubule associated serine/threonine kinase family member 4
MRPS2 mitochondrial ribosomal protein S2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
PRR7 proline rich 7 (synaptic)
PTPRD protein tyrosine phosphatase, receptor type, D
QPCT glutaminyl-peptide cyclotransferase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SMAD3 SMAD family member 3
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
UGCG UDP-glucose ceramide glucosyltransferase