BRD-A19633847_PERHEXILINE MALEATE_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACACA acetyl-CoA carboxylase alpha
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADIPOR2 adiponectin receptor 2
ALDOC aldolase C, fructose-bisphosphate
ALOX15B arachidonate 15-lipoxygenase, type B
ATF3 activating transcription factor 3
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BHLHE40 basic helix-loop-helix family, member e40
C10ORF10 chromosome 10 open reading frame 10
C14ORF1 chromosome 14 open reading frame 1
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD46 CD46 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
EBP emopamil binding protein (sterol isomerase)
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGFBP1 fibroblast growth factor binding protein 1
G6PD glucose-6-phosphate dehydrogenase
H1F0 H1 histone family, member 0
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KAT6B K(lysine) acetyltransferase 6B
KDM3A lysine (K)-specific demethylase 3A
KLK11 kallikrein-related peptidase 11
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PRKCH protein kinase C, eta
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHCG Rh family, C glycoprotein
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F2 solute carrier family 35, member F2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
STXBP1 syntaxin binding protein 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM135 transmembrane protein 135
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
VGLL4 vestigial-like family member 4
WBP2 WW domain binding protein 2

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AQP3 aquaporin 3 (Gill blood group)
CRIP1 cysteine-rich protein 1 (intestinal)
DNAAF2 dynein, axonemal, assembly factor 2
EIF5A eukaryotic translation initiation factor 5A
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GJA1 gap junction protein, alpha 1, 43kDa
GRWD1 glutamate-rich WD repeat containing 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOMER1 homer scaffolding protein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
PDLIM3 PDZ and LIM domain 3
POSTN periostin, osteoblast specific factor
PTDSS1 phosphatidylserine synthase 1
RELN reelin
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SRSF6 serine/arginine-rich splicing factor 6
SULF1 sulfatase 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZEB1 zinc finger E-box binding homeobox 1