BRD-A19633847_PERHEXILINE MALEATE_U937_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_U937_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIPOR2 adiponectin receptor 2
ALOX5 arachidonate 5-lipoxygenase
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C2CD5 C2 calcium-dependent domain containing 5
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DES desmin
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FBN2 fibrillin 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
GRN granulin
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
HSPA4 heat shock 70kDa protein 4
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KLHDC2 kelch domain containing 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19 keratin 19, type I
LOXL2 lysyl oxidase-like 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP3K7CL MAP3K7 C-terminal like
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
NEFL neurofilament, light polypeptide
NIT1 nitrilase 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNMA2 paraneoplastic Ma antigen 2
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
PXN paxillin
RAB13 RAB13, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RAI14 retinoic acid induced 14
RBPMS RNA binding protein with multiple splicing
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RPL38 ribosomal protein L38
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTN2 reticulon 2
SAMD4A sterile alpha motif domain containing 4A
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SDC2 syndecan 2
SDCBP syndecan binding protein (syntenin)
SGCE sarcoglycan, epsilon
SHB Src homology 2 domain containing adaptor protein B
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC1A structural maintenance of chromosomes 1A
SQSTM1 sequestosome 1
STON1 stonin 1
STX7 syntaxin 7
SWAP70 SWAP switching B-cell complex 70kDa subunit
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TNNT1 troponin T type 1 (skeletal, slow)
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TULP3 tubby like protein 3
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WASF1 WAS protein family, member 1
YPEL5 yippee-like 5 (Drosophila)
ZBED2 zinc finger, BED-type containing 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BOP1 block of proliferation 1
C2CD2 C2 calcium-dependent domain containing 2
CD36 CD36 molecule (thrombospondin receptor)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHPT1 choline phosphotransferase 1
COBL cordon-bleu WH2 repeat protein
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
EDF1 endothelial differentiation-related factor 1
ENDOD1 endonuclease domain containing 1
ESR1 estrogen receptor 1
FAM120A family with sequence similarity 120A
FAM98A family with sequence similarity 98, member A
FXYD3 FXYD domain containing ion transport regulator 3
FYB FYN binding protein
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GOLM1 golgi membrane protein 1
GTF2H5 general transcription factor IIH, polypeptide 5
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KRT10 keratin 10, type I
LARS leucyl-tRNA synthetase
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MARCKSL1 MARCKS-like 1
MINA MYC induced nuclear antigen
MMP12 matrix metallopeptidase 12
MRPS2 mitochondrial ribosomal protein S2
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NAAA N-acylethanolamine acid amidase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP98 nucleoporin 98kDa
PLAC8 placenta-specific 8
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPL26L1 ribosomal protein L26-like 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSAD1 radical S-adenosyl methionine domain containing 1
SACS sacsin molecular chaperone
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLIRP SRA stem-loop interacting RNA binding protein
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORD sorbitol dehydrogenase
SPEN spen family transcriptional repressor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM5 transmembrane protein 5
TPD52L1 tumor protein D52-like 1
TPRKB TP53RK binding protein
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta